Skip to main content
EJNMMI Research

Table 3 Intra-rater agreement of [99mTc]NM-01 measurements

From: Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer

SPECT

Rater A

Rater B

Rater C

1 SUVmax (mean ± SD)

2 SUVmax (mean ± SD)

ICC (95% CI)

1 SUVmax (mean ± SD)

2 SUVmax (mean ± SD)

ICC (95% CI)

1 SUVmax (mean ± SD)

2 SUVmax (mean ± SD)

ICC (95% CI)

Malignant lesion(s)

         

Primary lung tumour (T)

3.58 ± 1.27

3.62 ± 1.24

1.00 (0.99–1.00

3.57 ± 1.28

3.56 ± 1.30

1.00 (1.00–1.00)

3.62 ± 1.25

3.61 ± 1.25

1.00 (1.00–1.00)

Lymph node metastasis (LN)

3.23 ± 1.50

3.23 ± 1.51

0.99 (0.99–1.00)

3.19 ± 1.53

3.22 ± 1.53

0.99 (0.99–1.00)

3.36 ± 1.47

3.33 ± 1.49

1.00 (0.99–1.00)

Thoracic metastasis

2.72 ± 1.16

2.80 ± 1.20

0.97 (0.89–0.99)

2.79 ± 1.24

2.65 ± 1.09

0.97 (0.88–0.99)

2.70 ± 1.19

2.64 ± 1.05

0.98 (0.92–1.00)

Distant metastasis

4.30 ± 2.05

4.25 ± 2.00

0.97 (0.93–0.99)

4.25 ± 2.00

4.02 ± 2.19

0.94 (0.86–0.98)

4.42 ± 2.09

4.50 ± 2.21

0.99 (0.98–1.00)

Reference tissues

         

Blood pool (BP)

1.43 ± 0.50

1.47 ± 0.42

0.90 (0.80–0.96)

1.46 ± 0.48

1.42 ± 0.46

0.98 (0.95–0.99)

1.35 ± 0.37

1.39 ± 0.43

0.97 (0.93–0.99)

Lung (freehand)

1.72 ± 0.58

1.80 ± 0.62

0.90 (0.79–0.96)

1.69 ± 0.57

1.61 ± 0.52

0.86 (0.70–0.93)

1.38 ± 0.50

1.37 ± 0.49

1.00 (0.99–1.00)

Lung (AA)

1.38 ± 0.53

1.34 ± 0.48

0.96 (0.90–0.98)

1.38 ± 0.50

1.37 ± 0.52

0.96 (0.91–0.98)

1.36 ± 0.58

1.35 ± 0.59

0.99 (0.97–0.99)

Lung (C)

1.39 ± 0.49

1.38 ± 0.49

0.98 (0.95–0.99

1.34 ± 0.55

1.33 ± 0.45

0.94 (0.86–0.97)

1.46 ± 0.53

1.42 ± 0.51

0.98 (0.96–0.99)

Liver (freehand)

6.26 ± 1.34

6.29 ± 1.30

0.94 (0.86–0.97)

6.56 ± 1.33

6.66 ± 1.29

0.99 (0.96–0.99)

6.28 ± 1.23

6.27 ± 1.24

0.99 (0.99–1.00)

Liver (GOJ)

5.28 ± 1.03

5.27 ± 1.10

0.90 (0.79–0.96)

5.25 ± 1.21

5.29 ± 1.27

0.98 (0.96–0.99)

5.30 ± 1.06

5.27 ± 1.01

0.96 (0.92–0.98)

Spleen (freehand)

20.11 ± 4.18

21.02 ± 4.25

0.91 (0.76–0.97)

20.47 ± 3.97

20.57 ± 3.91

0.99 (0.98–1.00)

21.11 ± 3.84

20.68 ± 3.71

0.97 (0.91–0.99)

Spleen (volume)

18.89 ± 3.45

18.97 ± 3.53

0.95 (0.89–0.98)

19.10 ± 3.62

19.10 ± 3.51

0.96 (0.90–0.98)

19.38 ± 3.75

19.18 ± 3.67

0.97 (0.93–0.99)

Bone marrow (freehand)

3.35 ± 0.80

3.39 ± 0.78

0.91 (0.80–0.96)

3.52 ± 0.82

3.51 ± 0.83

0.99 (0.97–0.99)

3.55 ± 0.75

3.44 ± 0.86

0.90 (0.79–0.96)

Bone marrow (volume)

3.36 ± 0.79

3.38 ± 0.78

0.91 (0.80–0.96)

3.50 ± 0.83

3.52 ± 0.84

0.98 (0.96–0.99)

3.50 ± 0.77

3.36 ± 0.86

0.91 (0.79–0.96)

 

SUVmax ratio (mean ± SD)

SUVmax ratio (mean ± SD)

ICC (95% CI)

SUVmax ratio (mean ± SD)

SUVmax ratio (mean ± SD)

ICC (95% CI)

SUVmax ratio (mean ± SD)

SUVmax ratio (mean ± SD)

ICC (95% CI)

Ratios

         

T:BP

2.60 ± 0.82

2.52 ± 0.74

0.86 (0.71–0.94)

2.56 ± 0.87

2.61 ± 0.89

0.97 (0.92–0.98)

2.73 ± 0.77

2.68 ± 0.78

0.99 (0.97–0.99)

T:L (freehand)

2.35 ± 0.92

2.12 ± 0.89

0.87 (0.74–0.94)

2.27 ± 0.91

2.39 ± 1.04

0.92 (0.82–0.96)

2.86 ± 1.17

2.87 ± 1.16

1.00 (0.99–1.00)

T:L (AA)

2.89 ± 1.24

3.01 ± 1.28

0.97 (0.94–0.99)

2.83 ± 1.14

2.89 ± 1.22

0.96 (0.92–0.98)

3.03 ± 1.39

3.04 ± 1.42

0.99 (0.97–0.99)

T:L (C)

2.80 ± 1.10

2.85 ± 1.12

0.96 (0.92–0.98)

2.99 ± 1.28

2.90 ± 1.17

0.95 (0.89–0.98)

2.73 ± 1.20

2.83 ± 1.36

0.97 (0.93–0.99)

LN:BP

2.57 ± 1.43

2.35 ± 1.27

0.94 (0.87–0.97)

2.37 ± 1.28

2.50 ± 1.34

0.98 (0.95–0.99)

2.57 ± 1.10

2.52 ± 1.15

0.98 (0.97–0.99)

Thoracic met:BP

2.17 ± 1.11

2.06 ± 0.90

0.95 (0.82–0.99)

2.27 ± 1.25

2.04 ± 1.06

0.95 (0.72–0.99)

2.24 ± 1.01

2.17 ± 0.90

0.99 (0.94–1.00)

Distant met:BP

2.80 ± 1.62

2.84 ± 1.41

0.89 (0.75–0.96)

2.94 ± 1.75

2.86 ± 2.09

0.96 (0.91–0.98)

3.12 ± 1.65

3.13 ± 1.81

0.98 (0.96–0.99)

Spleen:Liver (freehand)

3.33 ± 0.99

3.46 ± 0.99

0.94 (0.86–0.97)

3.21 ± 0.74

3.17 ± 0.73

0.99 (0.98–1.00)

3.45 ± 0.77

3.37 ± 0.69

0.96 (0.92–0.98)

Spleen:Liver (volume)

3.65 ± 0.76

3.68 ± 0.74

0.84 (0.67–0.93)

3.72 ± 0.69

3.72 ± 0.77

0.93 (0.84–0.97)

3.73 ± 0.81

3.70 ± 0.74

0.96 (0.90–0.98)

Bone marrow:Liver (freehand)

0.55 ± 0.14

0.55 ± 0.13

0.86 (0.70–0.93)

0.55 ± 0.13

0.54 ± 0.13

0.97 (0.94–0.99)

0.58 ± 0.12

0.56 ± 0.13

0.90 (0.79–0.96)

Bone marrow:Liver (volume)

0.65 ± 0.15

0.65 ± 0.13

0.77 (0.55–0.89)

0.68 ± 0.15

0.68 ± 0.16

0.98 (0.95–0.99)

0.67 ± 0.14

0.64 ± 0.15

0.90 (0.77–0.95)

  1. Malignant lesion and healthy tissue reference measurements (SUVmax; mean ± SD) and their ratios, of all three raters from two timepoints, with intraclass correlation coefficient (ICC) and its 95% confidence interval (CI). ICC > 0.9 indicates excellent, 0.75 to < 0.9 good, 0.5 to < 0.75 moderate, and < 0.5 poor agreement
  2. AA aortic arch, BP blood pool, C carina, CI confidence interval, ICC intraclass correlation coefficient, GOJ gastroesophageal junction, L lung, LN lymph node metastasis, ROI region of interest, T primary lung tumour
Back to article page