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Table 2 Inter-rater agreement of [99mTc]NM-01 measurements

From: Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer

 

Rater A

Rater B

Rater C

  

SPECT

SUVmax (mean ± SD)

SUVmax (mean ± SD)

SUVmax (mean ± SD)

ICC (95% CI)

ICC Level of agreement

Malignant lesion(s) SUVmax

     

Primary lung tumour (T)

3.58 ± 1.27

3.57 ± 1.28

3.61 ± 1.25

1.00 (0.99–1.00)

Excellent

Lymph node metastasis (LN)

3.23 ± 1.50

3.19 ± 1.53

3.33 ± 1.49

0.97 (0.95–0.98)

Excellent

Thoracic metastasis

2.72 ± 1.62

2.79 ± 1.24

2.64 ± 1.05

0.94 (0.83–0.99)

Good to excellent

Distant metastasis

4.30 ± 2.05

4.25 ± 2.00

4.49 ± 2.21

0.91 (0.83–0.96)

Good to excellent

Reference tissues

     

Blood pool (BP)

1.43 ± 0.50

1.46 ± 0.48

1.39 ± 0.43

0.87 (0.76–0.94)

Good to excellent

Lung (freehand)

1.72 ± 0.58

1.69 ± 0.57

1.37 ± 0.49

0.93 (0.86–0.96)

Good to excellent

Lung (volume AA)

1.38 ± 0.53

1.38 ± 0.50

1.35 ± 0.59

0.88 (0.78–0.94)

Good to excellent

Lung (volume C)

1.39 ± 0.49

1.34 ± 0.55

1.42 ± 0.51

0.94 (0.88–0.97)

Good to excellent

Liver (freehand)

6.26 ± 1.34

6.56 ± 1.33

6.27 ± 1.24

0.93 (0.87–0.97)

Good to excellent

Liver (volume GOJ)

5.28 ± 1.03

5.25 ± 1.21

5.27 ± 1.01

0.90 (0.81–0.95)

Good to excellent

Spleen (freehand)

20.11 ± 4.18

20.47 ± 3.97

20.68 ± 3.71

0.90 (0.82–0.95)

Good to excellent

Spleen (volume)

18.89 ± 3.45

19.1 ± 3.62

19.18 ± 3.67

0.94 (0.88–0.97)

Good to excellent

Bone marrow (freehand)

3.35 ± 0.80

3.52 ± 0.82

3.44 ± 0.86

0.90 (0.82–0.95)

Good to excellent

Bone marrow (volume)

3.36 ± 0.79

3.50 ± 0.83

3.36 ± 0.86

0.93 (0.87–0.97)

Good to excellent

 

SUVmax ratio (mean ± SD)

SUVmax ratio (mean ± SD)

SUVmax ratio (mean ± SD)

ICC (95% CI)

ICC Level of agreement

Ratios

     

T:BP

2.60 ± 0.82

2.56 ± 0.87

2.68 ± 0.78

0.85 (0.73–0.93)

Moderate to excellent

T:L (freehand)

2.23 ± 0.92

2.27 ± 0.91

2.87 ± 1.16

0.91 (0.83–0.96)

Good to excellent

T:L (AA)

2.89 ± 1.24

2.83 ± 1.14

3.04 ± 1.42

0.88 (0.79–0.94)

Good to excellent

T:L (C)

2.80 ± 1.10

2.99 ± 1.28

2.83 ± 1.36

0.89 (0.80–0.95)

Good to excellent

LN:BP

2.57 ± 1.43

2.37 ± 1.28

2.52 ± 1.15

0.90 (0.85–0.94)

Good to excellent

Thoracic Met:BP

2.17 ± 1.11

2.27 ± 1.25

2.17 ± 0.90

0.94 (0.81–0.98)

Good to excellent

Distant Met:BP

2.80 ± 1.62

2.94 ± 1.75

3.13 ± 1.81

0.88 (0.77–0.94)

Good to excellent

Spleen:Liver

3.33 ± 0.99

3.21 ± 0.74

3.37 ± 0.69

0.78 (0.63–0.89)

Moderate to good

Bone marrow:Liver

0.55 ± 0.14

0.55 ± 0.13

0.56 ± 0.13

0.86 (0.75–0.93)

Good to excellent

  1. Primary tumour, thoracic lymph node, thoracic or distant metastases and healthy tissue reference measurements (SUVmax; mean ± SD) and their ratios of all three raters with intraclass correlation coefficient (ICC), their 95% confidence interval (CI) and descriptive ICC level of agreement
  2. AA aortic arch, BP blood pool, C carina, CI confidence interval, ICC intraclass correlation coefficient, GOJ gastroesophageal junction, L lung, LN lymph node metastasis, ROI region of interest, T primary lung tumour