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EJNMMI Research
Fig. 3 | EJNMMI Research

Fig. 3

From: A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

Fig. 3

Molecular model of the cyclic DX600 peptide bound to ACE2 (left). The peptide is shown as a red cartoon and the protein is shown as cartoons and a translucent molecular surface. The central closed structured loop of DX600 results from a disulfide bridge between Cys6 and Cys17 (shown as sticks) and contains the PxRxxPW sequence motif (shown as sticks) that binds the catalytic site of ACE2. As a result, the N terminus of DX600 is solvent-exposed and accessible for modification with a chelator for radiometalation (in the figure, through a lysine-coupled HBED-CC shown as sticks enabling the coordination of gallium shown as a green sphere). An additional molecular model shows the Ga-HBED-CC-DX600 peptide structure separately (right)

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