Table 1 General characteristics of the study patients (n = 103) and univariate Cox regression analysis for mandibular relapse-free survival
Characteristic | n (%) | HR (95% CI) | P | |
|---|---|---|---|---|
Age at diagnosis | ≤ 52 years | 45 (43.69) | 3.87 (1.59–9.42) | 0.003 |
> 52 years | 58 (56.31) | |||
Sex | Female | 5 (4.9) | ||
Male | 98 (95.1) | 22.76 (0.02–34,393) | 0.403 | |
History of smoking | Yes | 88 (85.44) | 2.64 (0.61–11.37) | 0.193 |
History of alcohol use | Yes | 72 (69.90) | 0.86 (0.38–1.97) | 0.722 |
Diabetes | Yes | 24 (23.30) | 0.95 (0.35–2.55) | 0.914 |
Cancer sites | Buccal | 36 (34.95) | 1.07 (0.46–2.46) | 0.882 |
Tongue | 29 (28.16) | |||
Gum | 22 (21.36) | |||
Mouth floor | 8 (7.77) | |||
Other sites* | 8 (7.77) | |||
T stage | T1–T2 | 32 (31.07) | ||
T3–T4 | 71 (68.93) | 2.95 (0.87–9.98) | 0.081 | |
N stage | N-negative | 51 (49.51) | ||
N-positive | 52 (50.49) | 1.01 (0.45–2.27) | 0.983 | |
AJCC stage | I–II | 16 (15.53) | ||
III–IV | 87 (84.47) | 1.28 (0.38–4.35) | 0.689 | |
Primary treatment | Surgery plus CCRT | 76 (73.79) | 0.45 (0.19–1.06) | 0.067 |
Surgery plus RT | 18 (17.48) | |||
IC plus CCRT | 7 (6.80) | |||
CCRT | 2 (1.94) | |||
SUVmax voxel site | Soft tissue predominance | 60 (58.25) | 5.08 (1.51–17.08) | 0.009 |
Bone predominance | 43 (41.75) | |||
PET/CT parameters | SUVmax > 12.35 | 36 (34.95) | 4.22 (1.74–10.23) | 0.001 |
SUVmax ≤ 12.35 | 67 (65.05) | |||
TLG > 62.68 | 25 (24.27) | 7.23 (3.08–16.98) | < 0.001 | |
TLG ≤ 62.68 | 78 (75.73) | |||