Parameter | Fixed or fitted (*) value [range used in predictions] | |
---|---|---|
Compound-specific | [68Ga]Ga-DOTATATE | [68Ga]Ga-HA-DOTATATE |
Molecular weight | 1502.3Â g/mol | 1628.5Â g/mol |
Lipophilicity | − 3.69 | − 3.12 |
KD | 0.20Â nmol/L | 0.23Â nmol/L * |
koff | 0.012 min−1 | 0.0071 min−1 * |
kint | 0.161 min−1 | 0.268 min−1 |
kdeg | 0.00012 min−1 | 0.00012 min−1 |
Fraction unbound | 0.69 | 0.69 |
System-specific | Primary tumor | Liver metastases | Other metastases |
---|---|---|---|
Fraction vascular | 0.21 [0.09–0.34] | 0.17 [0.1–0.23] | 0.075 [0.025–0.125] |
Fraction interstitial | 0.3 | 0.3 | 0.3 |
Blood flow | 152 mL/min/100 g [53–252] | 203 mL/min/100 g [139–363] | 152 mL/min/100 g [53–252] |
SSTR concentration (interstitial) | 168Â nmol/L | 224Â nmol/L | 224Â nmol/L |