Impact of framing scheme optimization and smoking status on binding potential analysis in dynamic PET with [11C]ABP688

EJNMMI Research

Table 2 Results for smoking status effects on BP_ND in different brain regions separated into HC and SZ groups and with framing schemes applied

Group	Framing scheme	Affected brain region	F-test	P-value	η²p*
HC	Const 5 min	Temporal right	5.867	0.030	0.295
HC	Const 5 min	Motor cortex	4.677	0.048	0.250
SZ	Const 5 min	Temporal left	10.693	0.006	0.433
		Temporal right	7.551	0.016	0.350
		Temporal middle	5.039	0.041	0.265
		Caudate	4.849	0.045	0.257
HC	Const Trues	Temporal left	11.086	0.005	0.442
		Temporal right	9.471	0.008	0.404
		Temporal middle	7.010	0.019	0.334
SZ	Const Trues	Whole brain GM	7.019	0.019	0.334
		Frontal left	12.911	0.003	0.480
		Frontal right	18.371	< 0.001	0.568
		Parietal left	7.233	0.018	0.341
		Parietal right	13.766	0.002	0.496
		Temporal left	32.300	< 0.001	0.698
		Temporal right	20.491	< 0.001	0.594
		Temporal middle	16.253	0.001	0.537
		Primary auditory	35.933	< 0.001	0.720
		ACC	8.220	0.012	0.370
		PCC	18.291	< 0.001	0.566
		Caudate	10.589	0.006	0.431
		Putamen	9.192	0.009	0.396

*Effect size
Table 2 Groups balanced by smoking status, age, gender and education for the analysis of smoking status effects on BP_ND in HC and SZ grouped by framing scheme methods. The results from a pairwise analysis between subgroups (S and nS) for brain regions with significant differences reported