Table 5 Percent change of the estimated parameters and curve fitting error by 50% and 200% of the fixed values
Drug | Parameter | \(k_{{{\text{off}}}}\) | \(k_{{{\text{off}}}}\) | \(k_{{{\text{off}}}}^{{\text{D}}}\) | \(k_{{{\text{off}}}}^{{\text{D}}}\) | \(K_{{\text{D}}}\) | \(K_{{\text{D}}}\) | \(K_{{\text{D}}}^{{\text{D}}}\) | \(K_{{\text{D}}}^{{\text{D}}}\) | \(f_{{\text{P}}}^{{\text{D}}}\) | \(f_{{{\text{ND}}}}^{{\text{D}}}\) |
|---|---|---|---|---|---|---|---|---|---|---|---|
50% | 200% | 50% | 200% | 50% | 200% | 50% | 200% | 50% | 50% | ||
LEV | \(V_{{\text{T}}}\) | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 1 ± 1 | − 2 ± 1 | 0 ± 1 | − 1 ± 1 |
LEV | \(f_{{{\text{ND}}}}\) | − 1 ± 2 | 0 ± 1 | − 2 ± 3 | 0 ± 2 | 0 ± 1 | 0 ± 1 | − 21 ± 5 | 134 ± 78 | 145 ± 96 | 0 ± 1 |
LEV | \(K_{1} \left( {{\text{disp}}.} \right)\) | 1 ± 1 | 0 ± 0 | 0 ± 1 | 0 ± 1 | 0 ± 0 | 0 ± 0 | − 1 ± 1 | 1 ± 1 | 0 ± 1 | 0 ± 0 |
LEV | \(K_{1} \left( {{\text{post}}.} \right)\) | 1 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 1 ± 1 | 1 ± 1 | 0 ± 0 |
LEV | \(K_{1}^{{\text{D}}}\) | 1 ± 6 | − 1 ± 6 | 2 ± 9 | − 1 ± 6 | 0 ± 4 | 0 ± 5 | − 37 ± 5 | 44 ± 7 | − 24 ± 6 | 96 ± 9 |
LEV | SS | 0 ± 0 | 0 ± 0 | 0 ± 1 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 1 ± 0 | 0 ± 1 | 0 ± 1 | 0 ± 0 |
BRV | \(V_{{\text{T}}}\) | − 1 ± 2 | − 1 ± 3 | 0 ± 2 | 0 ± 1 | 0 ± 2 | 0 ± 2 | 2 ± 3 | − 7 ± 7 | − 7 ± 7 | 0 ± 2 |
BRV | \(f_{{{\text{ND}}}}\) | − 3 ± 7 | − 2 ± 10 | 1 ± 7 | 2 ± 8 | 1 ± 7 | 1 ± 7 | − 34 ± 18 | 253 ± 208 | 266 ± 215 | − 1 ± 9 |
BRV | \(K_{1} \left( {{\text{disp}}.} \right)\) | 1 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | − 1 ± 1 | 3 ± 3 | 3 ± 3 | 0 ± 1 |
BRV | \(K_{1} \left( {{\text{post}}.} \right)\) | 0 ± 1 | 0 ± 0 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 0 ± 1 | 1 ± 2 | − 2 ± 3 | − 2 ± 3 | 0 ± 0 |
BRV | \(K_{1}^{{\text{D}}}\) | − 2 ± 12 | − 5 ± 11 | 2 ± 9 | − 2 ± 10 | − 3 ± 15 | − 1 ± 11 | 58 ± 96 | − 18 ± 33 | − 57 ± 15 | 87 ± 27 |
BRV | SS | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 1 | 6 ± 6 | 6 ± 6 | 0 ± 0 |