Table 4 Maximum target occupancies by AEDs and time to reach maximum and half occupancy after AED administration
Drug | Dose (mg) | Maximum occupancy (%) | Time to reach maximum occupancy (min) | Time to reach half occupancy (min) |
|---|---|---|---|---|
LEV | 1500 | 84 ± 2 | 277 ± 48 | 6.8 ± 0.8 |
BRV | 50 | 63 ± 1 | 38 ± 10 | 4.1 ± 0.3 |
BRV | 100 | 81 ± 3 | 21 ± 14 | 3.2 ± 0.4 |
BRV | 200 | 92 ± 2 | 29 ± 15 | 1.9 ± 0.5 |