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EJNMMI Research

Table 3 Test–retest reproducibility of binding parameters

From: Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

Region

VT (mL/cm3) (n = 4)

K1 (mL/cm3/min) (n = 4)

7-parameter model

5-parameter model

1TC

7-parameter

5-parameter

1TC

Putamen

− 4 ± 6%

− 1 ± 6%

2 ± 9%

− 2 ± 9%

− 3 ± 8%

− 4 ± 8%

Frontal cortex

− 2 ± 7%

− 2 ± 6%

0 ± 7%

− 2 ± 9%

− 2 ± 10%

− 2 ± 11%

Cerebellum

3 ± 12%

0 ± 9%

2 ± 7%

*− 5 ± 10%

− 2 ± 8%

− 3 ± 6%

  1. Data are mean and SD of test–retest reproducibility computed using \(\left({\text{test}}-{\text{retest}}\right)/\left({\text{test}}+{\text{retest}}\right)\times 2\)
  2. *n = 3
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