Table 1 Variables and functions and descriptions
Variables and functions | Description |
|---|---|
\(B_{{{\text{free}}}} \left( t \right)\) | Free SV2A concentration in tissue (nmol/L) |
\(B_{{{\text{max}}}}\) | Total SV2A concentration in tissue (nmol/L) |
\(C_{{{\text{ND}}}} \left( t \right)\) | Radioactivity concentration of non-displaceable tracer in tissue (Bq/cm3) |
\(C_{{\text{P}}} \left( t \right)\) | Radioactivity concentration of unmetabolized tracer in plasma (Bq/mL) |
\(C_{{\text{S}}} \left( t \right)\) | Radioactivity concentration of specifically bound tracer in tissue (Bq/cm3) |
\(D_{{{\text{ND}}}} \left( t \right)\) | Concentration of non-displaceable AED in tissue (nmol/L) |
\(D_{{\text{P}}} \left( t \right)\) | Concentration of unmetabolized AED in plasma (nmol/L) |
\(D_{{\text{S}}} \left( t \right)\) | Concentration of specifically bound AED in tissue (nmol/L) |
\(f_{{{\text{ND}}}}\) | Free fraction of tracer in non-displaceable compartment |
\(f_{{{\text{ND}}}}^{{\text{D}}}\) | Free fraction of AED in non-displaceable compartment |
\(f_{{\text{P}}}\) | Free fraction of tracer in plasma |
\(f_{{\text{P}}}^{{\text{D}}}\) | Free fraction of AED in plasma |
\(K_{1}\) | Rate constant of tracer for transfer from plasma to tissue (mL plasma/min/cm3 tissue) |
\(K_{1}^{{\text{D}}}\) | Rate constant of AED for transfer from plasma to tissue (mL plasma/min/cm3 tissue) |
\(k_{2}\) | Rate constant of tracer for transfer from tissue to plasma (1/min) |
\(k_{2}^{{\text{D}}}\) | Rate constant of AED for transfer from tissue to plasma (1/min) |
\(K_{{\text{D}}}\) | Dissociation constant of tracer in tissue (nmol/L) |
\(K_{{\text{D}}}^{{\text{D}}}\) | Dissociation constant of AED in tissue (nmol/L) |
\(k_{{{\text{off}}}}\) | Dissociation rate of tracer from SV2A binding sites (1/min) |
\(k_{{{\text{off}}}}^{{\text{D}}}\) | Dissociation rate of AED from SV2A binding sites (1/min) |
\(k_{{{\text{on}}}}\) | Bimolecular association rate constant for tracer (1/nmol/L/min) |
\(k_{{{\text{on}}}}^{{\text{D}}}\) | Bimolecular association rate constant for AED (1/nmol/L/min) |
M | Molar activity (MBq/µmol) |
\(O\left( t \right)\) | Target occupancy (%) |