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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

Fig. 2

a–d 11C-UCB-J activity curves in the frontal cortex (closed circles) with model fits (solid curves). a and b Displacement (LEV, 1500 mg at 60 min) and post-dose scans, c and d displacement (BRV, 200 mg at 60 min) and post-dose scans. CND(t) and CS(t) are displayed in the dotted and dashed curves, respectively. e–h Concentrations of AED in the plasma and non-displaceable AED in the frontal cortex (DND(t)) and occupancy curves (O(t)) by LEV (e, f) and BRV (g, h). Insets in f and h show the occupancy curves for the first 2 h

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