Fig. 2

⁶⁸Ga-PSMA PET and ¹⁷⁷Lu-PSMA biodistribution in mice. A Mice bearing subcutaneous C4-2 tumors were imaged 1 h after administration of ⁶⁸Ga-PSMA-TO-1/-11/-617 on consecutive days in the same 3 mice. B Corresponding tumor percent injected activity per gram (%IA/g). Mean tumor uptake for PSMA-TO-1, PSMA-11 and PSMA-617 was 11.27, 8.92 and 15.46%IA/g, respectively (not statistically different; p > 0.06). C Non-decay-corrected tumor and organ %IA/g in mice treated with 30 MBq ¹⁷⁷Lu-PSMA-617 (left) or 30 MBq ¹⁷⁷Lu-PSMA-TO-1 (right) (n = 5 mice/time point per ligand; bar graphs show mean ± SD). All other organs not shown measured %IA/g < 0.4% at their peak and uptake values for all organs are available in Additional file 1: Tables S1 and S2