Fig. 9

Effect of Trk inhibition in the presence of amitriptyline. A Effect on KM12 tumor uptake of [¹⁸F]TRACK. Representative PET images as coronal and sagittal projections at 60 min after injection of 5–7 MBq [¹⁸F]TRACK into KM12 tumor-bearing mice. Control image (left), after injection of 15 mg/kg amitriptyline (middle) and after combined injection of 15 mg/kg amitriptyline plus 5 mg/kg entrectinib (right). Below corresponding time–activity curves (TACs) for the radioactivity tumor uptake profiles and the semi-quantified data depicting the single SUV_mean at 60 min post-injection. B Effect on BAT uptake of [¹⁸F]TRACK. Representative PET images as maximum intensity projections (MIP) at 60 min post-injection of 5–7 MBq [¹⁸F]TRACK into wild-type control mice. Control image (left), after injection of 15 mg/kg amitriptyline (middle) and after combined injection of 15 mg/kg amitriptyline plus 5 mg/kg entrectinib (right). Below corresponding time–activity curves (TACs) for the radioactivity tumor uptake profiles and the semi-quantified data depicting the single SUV_mean at 60 min post-injection. All graphical data are shown as mean ± SEM from 3 to 5 experiments