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EJNMMI Research

Table 4 Organ-specific allometric parameters, and corresponding uncertainties, calculated using combined experimental [68Ga]NODAGA-RGDyK biodistribution data from mice and humans

From: Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

Organ

τb,m (h)

τb,m

τb,h (h)

στb,h

kb

Δkb

α'

Δα'

β′

Δβ′

Liver

15.12

4.54

4.91

1.84

0.32

0.16

− 0.14

0.06

− 0.06

0.05

Kidneys

0.69

0.21

2.38

0.66

3.42

1.39

0.16

0.05

0.07

0.08

Lung

0.69

0.21

1.94

0.10

2.79

0.85

0.13

0.04

0.19

0.04

Spleen

4.21

1.26

17.59

0.11

4.17

1.25

0.18

0.04

0.10

0.09

Heart wall

0.47

0.14

1.28

0.22

2.74

0.95

0.13

0.04

0.26

0.05

Stomach

0.69

0.21

4.29

5.45

6.17

8.06

0.23

0.16

0.00

0.06

Small intestine

1.19

0.36

4.07

1.90

3.14

1.89

0.16

0.07

0.06

0.05

Left Colon

0.60

0.18

3.50

1.40

5.87

2.94

0.22

0.06

0.06

0.05

Right colon

0.60

0.18

3.50

1.40

5.87

2.94

0.22

0.06

0.06

0.05

Rectum

0.60

0.18

3.50

1.40

5.87

2.94

0.22

0.06

0.06

0.05

Red marrow

0.53

0.16

11.65

3.58

22.4

9.46

0.39

0.05

0.07

0.04

Average of all values

      

0.17 (αnew)

0.06

0.08 (βmean)

0.05

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