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EJNMMI Research

Table 3 Comparison between mice-to-human dose extrapolations and dosimetry directly calculated on human subjects for [68Ga]NODAGA-RGDyK

From: Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules

68Ga-NODAGA-RGDyK

AD ratios

Target Organ

Human organ AD (mGy/MBq)

M1/H

M2/H

M3/H

M4/H

M5/H

Adrenals

1.55E−02

0.48

0.30

0.95

0.72

0.38

Brain

2.34E−03

0.72

0.80

2.61

3.15

1.60

Breasts

8.93E−03

0.23

0.24

0.76

0.89

0.46

Oesophagus

9.52E−03

0.30

0.27

0.81

0.87

0.45

Eyes

7.84E−03

0.22

0.24

0.78

0.94

0.48

Gallbladder Wall

1.17E−02

0.46

0.33

0.96

0.85

0.47

Left colon

2.57E−02

0.48

0.16

1.17

0.46

0.17

Small Intestine

4.37E−02

0.55

0.16

1.04

0.38

0.10

Stomach Wall

1.64E−02

0.56

0.22

1.32

0.64

0.28

Right colon

2.57E−02

0.49

0.16

1.19

0.46

0.18

Rectum

2.73E−02

0.57

0.28

1.21

0.56

0.16

Heart Wall

1.78E−02

0.25

0.21

0.61

0.58

0.26

Kidneys

4.74E−02

0.57

0.19

1.24

0.41

0.20

Liver

1.92E−02

1.46

0.83

1.67

0.97

0.81

Lungs

1.49E−02

0.28

0.40

0.59

0.91

0.28

Ovaries

1.28E−02

0.42

0.40

0.90

0.95

0.38

Pancreas

1.03E−02

0.43

0.31

1.02

0.92

0.49

Prostate

1.12E−02

0.52

0.51

0.96

1.02

0.35

Salivary Glands

8.36E−03

0.21

0.24

0.77

0.93

0.47

Red Marrow

1.06E−02

0.40

0.34

1.12

1.05

0.32

Osteogenic Cells

8.20E−03

0.34

0.31

1.03

1.01

0.36

Spleen

3.80E−02

0.44

0.26

0.61

0.37

0.12

Testes

8.24E−03

0.30

0.32

0.81

0.95

0.43

Thymus

9.72E−03

0.24

0.25

0.75

0.88

0.44

Thyroid

1.11E−02

0.17

0.19

0.60

0.72

0.36

Urinary Bladder Wall

1.04E−01

1.53

1.53

1.58

1.58

0.04

Uterus

1.52E−02

0.60

0.57

1.01

1.02

0.32

Total Body

1.10E−02

0.40

0.35

0.89

0.89

0.40

Average organ AD ratio

–

0.49

0.37

1.03

0.90

0.38

ED (mSv/MBq)

1.78E−02

0.74

0.60

1.17

0.93

0.24

  1. Source organ time-integrated activity coefficients obtained in five male patients were taken from [26], and used as input in OLINDA/EXM v.2.1 to derive absorbed doses (ADs) and effective doses (ED) to the gender average (GA) subject. AD ratios were calculated to compare different methods for mice-to-human extrapolations (M1-5) with ADs calculated on human subjects (H)
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