EJNMMI Research

Table 1 Dose of PF-06818883, plasma concentration of PF-06807893, and MAGL occupancy

From: Target occupancy study and whole-body dosimetry with a MAGL PET ligand [¹¹C]PF-06809247 in non-human primates

	Dose (mg/kg)	Conc (ng/mL)	2TC K_i (%)	Patlak slope (%)
NHP1	1.27	338.5	94.1	99.4
NHP2	1.27	370.0	90.8	100.5
NHP3	0.03	0.7	32.0	34.8
	0.14	10.3	91.5	99.3
NHP4	0.03	2.2	59.9	60.4
	0.42	45.6	94.1	98.8
NHP5	0.07	10.3	86.3	90.9
	0.01	–	22.8	25.4
NHP6	0.14	9.8	91.1	96.4
NHP7	0.055	1.4	47.8	49.9

NHP non-huma primate, Conc concentration of plasma, 2TC two-tissue compartment model

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