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Table 3 Comparisons of the individual organ uptake and tumour uptake in human biodistribution

From: Preclinical biodistribution and dosimetry and human biodistribution comparing 18F-rhPSMA-7 and single isomer 18F-rhPSMA-7.3

 

SUVmean

ratio-SUVmean

18F-rhPSMA-7 (n = 47)

18F-rhPSMA-7.3 (n = 33)

p-value*

18F-rhPSMA-7 (n = 47)

18F-rhPSMA-7.3 (n = 33)

p-value*

Background

0.63 ± 0.17

0.66 ± 0.13

0.0655

Parotid gland

16.94 ± 5.98

16.19 ± 4.42

0.5494

28.31 ± 11.15

25.46 ± 8.78

0.2296

Submandibular gland

19.62 ± 5.32

19.86 ± 5.45

0.8540

33.29 ± 12.34

31.00 ± 10.48

0.388

Blood pool

2.00 ± 2.26

1.85 ± 0.32

0.0282

3.18 ± 2.81

2.88 ± 0.69

0.6007

Lungs

0.68 ± 0.32

0.68 ± 0.19

0.5120

1.15 ± 0.63

1.04 ± 0.28

0.9492

Liver

6.98 ± 2.31

7.29 ± 2.24

0.5561

11.95 ± 6.12

11.39 ± 4.20

0.9571

Spleen

9.14 ± 3.24

8.44 ± 3.23

0.3382

15.12 ± 6.26

13.28 ± 5.69

0.1834

Kidneys

32.38 ± 9.33

35.74 ± 9.72

0.1953

55.17 ± 22.69

56.06 ± 18.15

0.8534

Pancreas

2.54 ± 0.87

2.84 ± 0.98

0.1772

4.27 ± 1.82

4.36 ± 1.47

0.5348

Duodenum

10.94 ± 4.22

10.96 ± 4.66

0.9813

18.36 ± 7.64

17.09 ± 7.88

0.4006

Bone

1.10 ± 0.33

1.34 ± 0.41

0.0050

1.81 ± 0.56

2.08 ± 0.71

0.0615

Bladder

4.59 ± 5.29

2.00 ± 0.78

0.0008

7.35 ± 7.79

3.09 ± 1.19

0.0002

Tumour

20.03 ± 20.23

32.54 ± 42.71

0.0711

35.97 ± 45.54

50.85 ± 68.65

0.1462

  1. Bold indicate that this are significant p-values (below 0.05)
  2. SUVmean: mean standardized uptake value; ratio-SUVmean: organ/tumour-to-background ratios with background being gluteus maximus muscle
  3. *Results of group comparisons from independent t-test or Mann–Whitney U test
  4. Normal distribution