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Table 3 Comparisons of the individual organ uptake and tumour uptake in human biodistribution

From: Preclinical biodistribution and dosimetry and human biodistribution comparing 18F-rhPSMA-7 and single isomer 18F-rhPSMA-7.3

  SUVmean ratio-SUVmean
18F-rhPSMA-7 (n = 47) 18F-rhPSMA-7.3 (n = 33) p-value* 18F-rhPSMA-7 (n = 47) 18F-rhPSMA-7.3 (n = 33) p-value*
Background 0.63 ± 0.17 0.66 ± 0.13 0.0655
Parotid gland 16.94 ± 5.98 16.19 ± 4.42 0.5494 28.31 ± 11.15 25.46 ± 8.78 0.2296
Submandibular gland 19.62 ± 5.32 19.86 ± 5.45 0.8540 33.29 ± 12.34 31.00 ± 10.48 0.388
Blood pool 2.00 ± 2.26 1.85 ± 0.32 0.0282 3.18 ± 2.81 2.88 ± 0.69 0.6007
Lungs 0.68 ± 0.32 0.68 ± 0.19 0.5120 1.15 ± 0.63 1.04 ± 0.28 0.9492
Liver 6.98 ± 2.31 7.29 ± 2.24 0.5561 11.95 ± 6.12 11.39 ± 4.20 0.9571
Spleen 9.14 ± 3.24 8.44 ± 3.23 0.3382 15.12 ± 6.26 13.28 ± 5.69 0.1834
Kidneys 32.38 ± 9.33 35.74 ± 9.72 0.1953 55.17 ± 22.69 56.06 ± 18.15 0.8534
Pancreas 2.54 ± 0.87 2.84 ± 0.98 0.1772 4.27 ± 1.82 4.36 ± 1.47 0.5348
Duodenum 10.94 ± 4.22 10.96 ± 4.66 0.9813 18.36 ± 7.64 17.09 ± 7.88 0.4006
Bone 1.10 ± 0.33 1.34 ± 0.41 0.0050 1.81 ± 0.56 2.08 ± 0.71 0.0615
Bladder 4.59 ± 5.29 2.00 ± 0.78 0.0008 7.35 ± 7.79 3.09 ± 1.19 0.0002
Tumour 20.03 ± 20.23 32.54 ± 42.71 0.0711 35.97 ± 45.54 50.85 ± 68.65 0.1462
  1. Bold indicate that this are significant p-values (below 0.05)
  2. SUVmean: mean standardized uptake value; ratio-SUVmean: organ/tumour-to-background ratios with background being gluteus maximus muscle
  3. *Results of group comparisons from independent t-test or Mann–Whitney U test
  4. Normal distribution