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Table 2 Summary of tumour hypoxic volume results using 4-h hypoxia PET-CT. Three thresholds were used to define progressively higher hypoxia PET tracer uptake: TBR ≥ 1.4 (a), TBR ≥ 1.6 (b), and TBR ≥ 1.8 (c)

From: Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

  Atovaquone cohort (n = 15) No atovaquone cohort (n = 15)
Centre Inner Outer Edge Centre Inner Outer Edge
(a)
 Baseline scan 15.2 (3.1–39.7) 29.8 (5.7–44.6) 18.1 (5.9–43.8) 0.0 (0.0–2.9) 2.2 (0.0–28.5) 6.0 (2.2–26.6) 7.3 (2.1–23.9) 0.0 (0.0–8.1)
 Pre-surgery scan 9.2 (0.0–32.1) 17.9 (1.5–23.4) 10.1 (1.9–27.2) 1.44 (0.0–3.4) 2.1 (0.0–32.1) 6.8 (2.3–23.4) 9.6 (2.3–27.2) 0.5 (0.0–11.4)
 Change from baseline − 10.4% (− 54.2 to − 1.05) − 33.3% (− 61.7 to 0.6) − 23.5% (− 49.4 to 0.5) 0.0% (− 33.7 to 4.6) 0.0% (− 5.6 to 9.6)  + 0.2% (− 9.1 to 22.2)  + 20.9% (− 0.4 to 29.8) 0.0% (− 13.7 to 7.0)
  Atovaquone cohort (n = 12) No atovaquone cohort (n = 11)
Centre Inner Outer Edge Centre Inner Outer Edge
(b)
 Baseline scan 9.3 (0.0–16.8) 10.2 (2.4–34.8) 20.8 (8.9–57.4) 0.0 (0.0–1.9) 2.4 (0.0–15.8) 2.5 (0.2–19.2) 6.1 (9.5–18.3) 0.0 (0.0–5.4)
 Pre-surgery scan 3.8 (0.0–17.6) 4.7 (0.3–29.7) 3.8 (0.6–32.1) 0.0 (0.0–2.4) 0.5 (0.0–13.0) 3.1 (0.6–15.4) 6.9 (1.0–19.1) 0.0 (0.0–5.2)
 Change from baseline − 11.3% (− 45.5 to 2.0) − 49.3% (− 66.9 to − 4.4) − 50.5% (− 61.6 to 2.1) 0.0% (− 28.9 to 29.6) 0.0% (− 11.3 to 8.5) 0.0% (− 18.2 to 28.8)  + 5.1% (− 10.3 to 34.8) 0.0% (− 8.5 to 8.0)
  Atovaquone cohort (n = 9) No atovaquone cohort (n = 8)
Centre Inner Outer Edge Centre Inner Outer Edge
(c)
 Baseline scan 3.5 (0.0–11.7) 2.0 (0.5–22.8) 4.0 (0.4–22.9) 0.0 (0.0–0.7) 0.0 (0.0–7.9) 1.4 (0.0–7.9) 0.5 (0.0–10.9) 0.0 (0.0–3.7)
 Pre-surgery scan 0.7 (0.0–11.2) 0.4 (0.0–14.6) 0.9 (0.0–13.3) 0.0 (0.0–0.0) 0.0 (0.0–6.5) 1.3 (0.1–7.6) 3.4 (0.3–10.3) 0.0 (0.0–6.5)
 Change from baseline − 14.8% (− 46.9 to 5.42) − 23.7% (− 65.9 to 6.6) − 81.0% (− 84.6 to − 5.6) 0.0% (− 41.6 to 24.3) 0.0% (− 19.6 to 8.7) 0.0% (− 23.8 to 10.5)  + 6.0% (− 18.8 to 12.8) 0.0% (− 7.2 to 7.4)
  1. Median values (mL) with IQR for baseline and pre-surgery scans, and median percentage change from baseline with 95% CI