Atovaquone cohort (n = 15) | No atovaquone cohort (n = 15) | |||||||
---|---|---|---|---|---|---|---|---|
Centre | Inner | Outer | Edge | Centre | Inner | Outer | Edge | |
(a) | ||||||||
Baseline scan | 15.2 (3.1–39.7) | 29.8 (5.7–44.6) | 18.1 (5.9–43.8) | 0.0 (0.0–2.9) | 2.2 (0.0–28.5) | 6.0 (2.2–26.6) | 7.3 (2.1–23.9) | 0.0 (0.0–8.1) |
Pre-surgery scan | 9.2 (0.0–32.1) | 17.9 (1.5–23.4) | 10.1 (1.9–27.2) | 1.44 (0.0–3.4) | 2.1 (0.0–32.1) | 6.8 (2.3–23.4) | 9.6 (2.3–27.2) | 0.5 (0.0–11.4) |
Change from baseline | − 10.4% (− 54.2 to − 1.05) | − 33.3% (− 61.7 to 0.6) | − 23.5% (− 49.4 to 0.5) | 0.0% (− 33.7 to 4.6) | 0.0% (− 5.6 to 9.6) | + 0.2% (− 9.1 to 22.2) | + 20.9% (− 0.4 to 29.8) | 0.0% (− 13.7 to 7.0) |
Atovaquone cohort (n = 12) | No atovaquone cohort (n = 11) | |||||||
---|---|---|---|---|---|---|---|---|
Centre | Inner | Outer | Edge | Centre | Inner | Outer | Edge | |
(b) | ||||||||
Baseline scan | 9.3 (0.0–16.8) | 10.2 (2.4–34.8) | 20.8 (8.9–57.4) | 0.0 (0.0–1.9) | 2.4 (0.0–15.8) | 2.5 (0.2–19.2) | 6.1 (9.5–18.3) | 0.0 (0.0–5.4) |
Pre-surgery scan | 3.8 (0.0–17.6) | 4.7 (0.3–29.7) | 3.8 (0.6–32.1) | 0.0 (0.0–2.4) | 0.5 (0.0–13.0) | 3.1 (0.6–15.4) | 6.9 (1.0–19.1) | 0.0 (0.0–5.2) |
Change from baseline | − 11.3% (− 45.5 to 2.0) | − 49.3% (− 66.9 to − 4.4) | − 50.5% (− 61.6 to 2.1) | 0.0% (− 28.9 to 29.6) | 0.0% (− 11.3 to 8.5) | 0.0% (− 18.2 to 28.8) | + 5.1% (− 10.3 to 34.8) | 0.0% (− 8.5 to 8.0) |
Atovaquone cohort (n = 9) | No atovaquone cohort (n = 8) | |||||||
---|---|---|---|---|---|---|---|---|
Centre | Inner | Outer | Edge | Centre | Inner | Outer | Edge | |
(c) | ||||||||
Baseline scan | 3.5 (0.0–11.7) | 2.0 (0.5–22.8) | 4.0 (0.4–22.9) | 0.0 (0.0–0.7) | 0.0 (0.0–7.9) | 1.4 (0.0–7.9) | 0.5 (0.0–10.9) | 0.0 (0.0–3.7) |
Pre-surgery scan | 0.7 (0.0–11.2) | 0.4 (0.0–14.6) | 0.9 (0.0–13.3) | 0.0 (0.0–0.0) | 0.0 (0.0–6.5) | 1.3 (0.1–7.6) | 3.4 (0.3–10.3) | 0.0 (0.0–6.5) |
Change from baseline | − 14.8% (− 46.9 to 5.42) | − 23.7% (− 65.9 to 6.6) | − 81.0% (− 84.6 to − 5.6) | 0.0% (− 41.6 to 24.3) | 0.0% (− 19.6 to 8.7) | 0.0% (− 23.8 to 10.5) | + 6.0% (− 18.8 to 12.8) | 0.0% (− 7.2 to 7.4) |