Fig. 3
Changes in the fraction of hypoxic voxels from baseline in atovaquone-treated (A) and untreated (B) patients. Tumour hypoxic voxels are divided into three groups (yellow, orange, red) according to their level of hypoxia defined by their TBR value. Statistical significances are only indicated for global changes in the mean fraction of hypoxic voxels between visits (i.e. baseline visit and pre-surgery visit named ‘pre’ and ‘post’, respectively) not all three TBR thresholds. **, P < 0.01; ns, non-significant