Fig. 1
From: Amyloid PET quantification using low-dose CT-guided anatomic standardization
Processing pipeline for quantitative measurements of 18F-flutemetamol accumulation in the cerebral cortex. The subject MRI or CT was oriented and coregistered to the MNI template. The subject PET was oriented and coregistered to the coregistered subject MRI or subject CT. Then, the coregistered subject MRI or subject CT was warped into MNI space using unified segmentation in SPM12. The parameters of the deformation field in this warping were applied to the coregistered subject PET for anatomical standardization into MNI space. SUVR was calculated from the 18F-flutemetamol PET counts in the cerebral cortical areas (Cortex VOI, CTX VOI) and in the whole cerebellum as a reference area (Reference VOI, WhlCbl VOI) using the GAAIN standard VOI template. Then, SUVR was converted to CL using a direct conversion equation. Processing with a black background was performed using Statistical Parametric Mapping (SPM) 12