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EJNMMI Research
Fig. 8 | EJNMMI Research

Fig. 8

From: There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

Fig. 8

Imaging of pancreatic cancer in humans (tumor positions indicated by arrows). A: 68 Ga-Avebetrin PET (144 MBq, 46 min p.i.) of a female patient with poorly differentiated PDAC, showing focal uptake in the tumor (SUVmax = 8.5) [106]. The uptake pattern in the organs is comparable to other αvβ3-integrin tracers [6] and most likely originates in physiological αvβ3-integrin expression. B: 68 Ga-Trivehexin PET (87 MBq, 70 min p.i.) of a male patient with histologically proven PDAC (SUVmax = 13.1) [109]. Apart from excretion-related activity in the kidneys, no significant organ uptakes are observed, which is in accordance with a generally low expression of αvβ6-integrin in adult human tissues

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