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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

Fig. 2

Examples of selective integrin ligands [15, 30,31,32,33,34] whose radiolabeled derivatives were developed and/or evaluated in the framework of CRC 824. Note that all addressed integrins (αvβ3, αvβ6, αvβ8, α5β1) belong to the class of RGD receptors (see Fig. 1), but not all of the peptides contain the RGD sequence, and one ligand (FR366) is not a peptide but a peptidomimetic. The colors highlight the RGD sequence or their structural equivalents, respectively. The dashed bonds on the terminal amines indicate the conjugation sites

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