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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Fig. 4

DHE and 18F-BCPP-EF uptake in various brain regions 24 h after QA injection. QA was injected into the striatum on the right side of the image, and saline was simultaneously injected into the contralateral striatum. A The accumulation of fluorescence in the QA-injected striatum 60 min after the intravenous injection of DHE. B Summation 18F-BCPP-EF PET images from 45 to 60 min were reconstructed to obtain standardised uptake value (SUV) images. C Semiquantitative analysis of the fluorescent images. The ROIs were identified based on the prefrontal cortex (a), frontal cortex (b), parietal cortex (c), hippocampus (d), thalamus (e), and cerebellum (f). Mean ± SD, n = 4. D; Radioactivity concentration for the time period from 45–60 min (SUV). The VOIs were identified based on the prefrontal cortex, frontal cortex, parietal cortex, hippocampus, thalamus, and cerebellum. Mean ± SD, n = 4. *P < 0.05, **P < 0.01 between the saline- and the QA-injected side using the Student’s paired t-test

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