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Table 2 Overview of trials reporting on preoperative nuclear medicine imaging and computed tomography or magnetic resonance imaging for the prediction of postoperative mortality

From: Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

Author Mortality defined Mortality event rate Preset cutoff studied Post hoc cutoff value established Only descriptive analysis Mortality versus no mortality comparison Key diagnostic characteristics reported CT/MRI or NMI predictive in univariable regression analysis CT/MRI or NMI predictive in multivariable regression analysis Comparison of predictive value
Dinant et al. [19] No 11% NMI/CT: No NMI: Yes
CT: No
No NMI/CT: Yes NMI/CT: Yes NMI: Yes
CT: NR
NMI: No
CT: NR
NR
Chapelle et al. [18] Yes 6% NMI/MRI: Noa NMI/MRI: Yesb Yes NR NR NR NR NR
Chapelle et al. [27] Yes 0%c NMI/MRI: Yesb NMI/MRI: No Yes NR NR NR NR NR
Cieslak et al. [21] Yes 7% NMI/CT: Yesb NMI/CT: No Yes NR NR NR NR NR
Fujioka et al. ≠ [33] No 7% NMI/CT: No NMI: Yesb
CT: No
Yes NR NR NR NR NR
Hayashi et al. [20] Yes 6% NMI/CT: Yesb NMI/CT: No No NMI/CT: NR NMI/CT: NR NMI: Yes
CT: No
NMI/CT: NR NR
Kwon et al. [34] No 2% NMI/CT: No NMI/CT: Yesb Yes NR NR NR NR NR
Kwon et al. [35] No 3% NMI/CT: No NMI/CT: Yesb Yes NR NR NR NR NR
Kwon et al. ≠ [36] No 1% NMI/CT: No NMI: Yesb
CT: No
Yes NR NR NR NR NR
Olthof et al. [22] Yes 18% NMI/CT: Yesb NMI: Yesb
CT: No
No NMI/CT: NR NMI: Yesb
CT: Yes
NMI/CT: NR NMI/CT: NR NR
Otsuki et al. [15] No 27% NMI/CT: No NMI: Yesb
CT: No
NMI: No
CT: Yes
NMI: Yes
CT: NR
NMI/CT: NR NMI/CT: NR NMI/CT: NR NR
Rassam et al. [23] Yes 11% NMI: Yesb
CT: No
NMI/CT: No No NMI/CT: Yes NMI/CT: NR NMI/CT: NR NMI/CT: NR NR
Truant et al. [38] No 14%d NMI/CT: No NMI/CT: No Yes NR NR NR NR NR
  1. NMI: nuclear medicine imaging; CT: computed tomography; MRI: magnetic resonance imaging; and NR: not reported
  2. aOnly patients with a preoperative FLRV% > 25% were resected and included in the study
  3. bThe cutoff value is set for both avoiding mortality and postoperative LF or overall complications/poor postoperative outcome in order to obtain a safe hepatectomy
  4. cNo patients in the interventional group died postoperatively, but in the 88 patients in the prior study by Chapelle et al. the mortality rate was 6%, also reported in the table above
  5. dPostoperative clinical outcomes were only reported in the seven patients who underwent ALPPS. One of the seven patients died due to LF postoperatively