Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

EJNMMI Research

Table 2 Overview of trials reporting on preoperative nuclear medicine imaging and computed tomography or magnetic resonance imaging for the prediction of postoperative mortality

Author	Mortality defined	Mortality event rate	Preset cutoff studied	Post hoc cutoff value established	Only descriptive analysis	Mortality versus no mortality comparison	Key diagnostic characteristics reported	CT/MRI or NMI predictive in univariable regression analysis	CT/MRI or NMI predictive in multivariable regression analysis	Comparison of predictive value
Dinant et al. [19]	No	11%	NMI/CT: No	NMI: Yes CT: No	No	NMI/CT: Yes	NMI/CT: Yes	NMI: Yes CT: NR	NMI: No CT: NR	NR
Chapelle et al. [18]	Yes	6%	NMI/MRI: No^a	NMI/MRI: Yes^b	Yes	NR	NR	NR	NR	NR
Chapelle et al. [27]	Yes	0%^c	NMI/MRI: Yes^b	NMI/MRI: No	Yes	NR	NR	NR	NR	NR
Cieslak et al. [21]	Yes	7%	NMI/CT: Yes^b	NMI/CT: No	Yes	NR	NR	NR	NR	NR
Fujioka et al. ≠ [33]	No	7%	NMI/CT: No	NMI: Yes^b CT: No	Yes	NR	NR	NR	NR	NR
Hayashi et al. [20]	Yes	6%	NMI/CT: Yes^b	NMI/CT: No	No	NMI/CT: NR	NMI/CT: NR	NMI: Yes CT: No	NMI/CT: NR	NR
Kwon et al. [34]	No	2%	NMI/CT: No	NMI/CT: Yes^b	Yes	NR	NR	NR	NR	NR
Kwon et al. [35]	No	3%	NMI/CT: No	NMI/CT: Yes^b	Yes	NR	NR	NR	NR	NR
Kwon et al. ≠ [36]	No	1%	NMI/CT: No	NMI: Yes^b CT: No	Yes	NR	NR	NR	NR	NR
Olthof et al. [22]	Yes	18%	NMI/CT: Yes^b	NMI: Yes^b CT: No	No	NMI/CT: NR	NMI: Yes^b CT: Yes	NMI/CT: NR	NMI/CT: NR	NR
Otsuki et al. [15]	No	27%	NMI/CT: No	NMI: Yes^b CT: No	NMI: No CT: Yes	NMI: Yes CT: NR	NMI/CT: NR	NMI/CT: NR	NMI/CT: NR	NR
Rassam et al. [23]	Yes	11%	NMI: Yes^b CT: No	NMI/CT: No	No	NMI/CT: Yes	NMI/CT: NR	NMI/CT: NR	NMI/CT: NR	NR
Truant et al. [38]	No	14%^d	NMI/CT: No	NMI/CT: No	Yes	NR	NR	NR	NR	NR

NMI: nuclear medicine imaging; CT: computed tomography; MRI: magnetic resonance imaging; and NR: not reported
^aOnly patients with a preoperative FLRV% > 25% were resected and included in the study
^bThe cutoff value is set for both avoiding mortality and postoperative LF or overall complications/poor postoperative outcome in order to obtain a safe hepatectomy
^cNo patients in the interventional group died postoperatively, but in the 88 patients in the prior study by Chapelle et al. the mortality rate was 6%, also reported in the table above
^dPostoperative clinical outcomes were only reported in the seven patients who underwent ALPPS. One of the seven patients died due to LF postoperatively