Fig. 2
From: Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example
Schematic structure of the mathematical model. The area within the dotted line contains the contributions to the measured PET signal. The dashed line indicates the border between vascular and interstitial space. On the left hand side of the dashed line a two-compartment plasma PK model characterizes systemic PK. The subscript j can be either l (labeled) referring to 89Zr-mAb or u (unlabeled) referring to mAb