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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

Fig. 1

a PET/CT scan of a patient administered with [18F]DCFPyL demonstrating uptake in the bladder, kidney, salivary (parotid, sublingual, submandibular, and minor/seromucous glands), and lacrimal glands. b Immunofluorescence staining of PSMA in human salivary glands (magenta: anti-PSMA staining on the apical lumen of acinar cells; teal: DAPI nuclei staining). c Cannulated submandibular salivary glands (SMG) of mouse and human illustrating similarity in delivery of preventive therapy in our model system. Black arrowhead indicates the inserted cannula. d and e Diagram of the cannulation procedure showing how delivered cold DCFPyL can access and block PSMA sites on the acinar cell surface

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