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Table 3. 201Tl radiotoxicity—nuclear DNA damage

From: In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201

Activity of 201Tl (kBq/mL) Average number of foci per nucleus (± SD) DU145 Average number of foci per nucleus (± SD) MDA-MB-231
0 3.5 ± 3.6 17.8 ± 18.3 11.9 ± 10.4 7.9 ± 10.3 8.6 ± 6.2 12.0 ± 10.9
100 5.2 ± 5 37.5 ± 25.2 13.3 ± 10.6 7.0 ± 5.3 9.4 ± 7.5 14.0 ± 13.1
200 4.4 ± 4.1 40.6 ± 33.7 12.0 ± 9.1 13.8 ± 8.0 9.5 ± 5.3 15.0 ± 7.2
400 16.2 ± 11.5 60.4 ± 34.9 19.9 ± 12.8 18.2 ± 9.4 22.7 ± 11.0 21.0 ± 12.2
1000 10.1 ± 6.2 71.2 ± 23.2 26.2 ± 18.1 30.9 ± 18.0 27.9 ± 17 38.8 ± 20.4
4000 28.6 ± 14.7 61.2 ± 27.8 25.3 ± 13.0 61.5 ± 28.0 29.6 ± 12.7 39.2 ± 21.5
  1. Average number of foci per nucleus in DU145 cells and MDA-MD-231 cells after 90 min incubation with various activities of [201Tl]TlCl in medium, and with 0.9% NaCl (0 kBq/mL) measured in three independent experiments