Table 3. 201Tl radiotoxicity—nuclear DNA damage
From: In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201
Activity of 201Tl (kBq/mL) | Average number of foci per nucleus (± SD) DU145 | Average number of foci per nucleus (± SD) MDA-MB-231 | ||||
|---|---|---|---|---|---|---|
0 | 3.5 ± 3.6 | 17.8 ± 18.3 | 11.9 ± 10.4 | 7.9 ± 10.3 | 8.6 ± 6.2 | 12.0 ± 10.9 |
100 | 5.2 ± 5 | 37.5 ± 25.2 | 13.3 ± 10.6 | 7.0 ± 5.3 | 9.4 ± 7.5 | 14.0 ± 13.1 |
200 | 4.4 ± 4.1 | 40.6 ± 33.7 | 12.0 ± 9.1 | 13.8 ± 8.0 | 9.5 ± 5.3 | 15.0 ± 7.2 |
400 | 16.2 ± 11.5 | 60.4 ± 34.9 | 19.9 ± 12.8 | 18.2 ± 9.4 | 22.7 ± 11.0 | 21.0 ± 12.2 |
1000 | 10.1 ± 6.2 | 71.2 ± 23.2 | 26.2 ± 18.1 | 30.9 ± 18.0 | 27.9 ± 17 | 38.8 ± 20.4 |
4000 | 28.6 ± 14.7 | 61.2 ± 27.8 | 25.3 ± 13.0 | 61.5 ± 28.0 | 29.6 ± 12.7 | 39.2 ± 21.5 |