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Table 3 Immunohistochemical results among different groups of lung cancer

From: [99mTc]Tc-Galacto-RGD2 integrin αvβ3-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data

 

Stage

Class

T/NT (1 h)

I-II (n = 21)

III-IV (n = 45)

p

LAC (n = 34)

LSC (n = 26)

SCLC (n = 6)

p

low (< 7.21) (n = 33)

high (≥ 7.21) (n = 33)

p

Integrin αvβ3 (OD)

5914.4 (1461.6, 17,658.2)

19,729.0 (6445.4, 45,288.3)

3.10E-02

17,308.1 (7973.6,47,755.9)

9721.6 (3186.5,23,010.7)

6485.0 (3083.0,28,119.0)

0.31

16,958.0 (3842.8,36,479.0)

12,235.4 (4935.2,47,323.5)

0.98

CXCR4 (OD)

8438.0 (2582.5,22,821.8)

4002 (1863,11,541)

0.18

4536 (1348,10,501)

9052.0 (3688.9,33,442.9)

2324 (1980,4395)

0.11

6561.00 (2049.20,18,854.50)

5007 (1335,15,314)

0.65

CD31 (MVD)

28.20 (14.25,34.40)

21.33 (13.75,32.00)

0.54

27.80 (14.44,34.35)

19.72 (15.06,32.11)

13.32 (11.75,20.04)

0.25

25.80 (15.00,35.40)

18.20 (13.75,28.40)

0.25

Ki67 (%)

11.00 (5.00,40.00)

22.82 (8.63,43.95)

0.47

10.15 (2.98,27.89)

27.45 (11.88,42.00)

70.00 (55.13,73.48)

5.64E-03

16.13 (4.36,50.00)

21.90 (10.00,38.90)

0.55

  1. Bold values indicate p values means there is a significance of the statistical results
  2. LAC adenocarcinoma, LSC squamous cell carcinoma, SCLC small cell lung cancer, OD optical density, MVD microvessel density. The non-normal distribution data showed as median (interquartile range)