Head to head comparison of [99mTc]Tc(CO)3(NTA) and [99mTc]Tc-MAG3 in patients with suspected obstruction

EJNMMI Research

Table 1 Dose injected (MBq) of [^99mTc]Tc(CO)₃(NTA) and [^99mTc]Tc-MAG3, serum creatinine, voided volume, percent uptake and the camera based clearance

Subject	Dose injected (MBq)		Creatinine (mg/dL)	Voided volume (mL)		Left kidney (%)		Right kidney (%)		Clearance (mL/min/1.73 m²)
Subject	NTA	MAG3		NTA	MAG3	NTA	MAG3	NTA	MAG3	NTA	MAG3
1	44.8	345.2	0.49	*	*	52	53	48	47	526	368
2	312.3	44.4	0.98	360	350	80	82	20	18	123	72
3	46.2	337.8	0.5	1000	600	48	47	52	53	468	323
4	46.2	320.1	NA	800	850	NA	NA	100	100	380	276
5	234.2	46.2	1.08	600	600	25	26	75	74	252	252
6	39.6	321.9	0.74	850	700	79	75	21	25	438	378
7	48.1	345.2	0.9	*	*	52	49	48	51	396	306
8	51.1	312.3	1.93	320	400	NA	NA	100	100	85	85
9	54.4	315.2	0.7	*	*	49	47	51	53	341	295
10	52.2	358.9	1.9	*	*	88	90	12	10	226	191
11	47.7	321.5	1.27	*	*	77	79	23	21	340	313
13	54.4	319.7	0.79	800	380	50	50	50	50	513	389
14	55.1	302.3	NA	*	*	58	50	42	50	259	238
15	53.6	286.7	1.24	500	550	28	29	72	71	150	149
16	57.0	346.3	0.78	450	350	48	46	52	54	456	378
17	58.1	388.5	2.44	360	350	51	56	49	44	226	233
18	58.8	357.1	2.01	360	300	64	63	36	37	218	188
19	53.3	359.3	1.01	780	550	57	60	43	40	566	441
Mean	NC	NC	1.17	598	498	56.6	56.4	49.7	49.9	331	271
SD			0.59	237	170	17.6	17.9	24.7	24.8	146	105
P				0.07		0.75		0.75		0.0002

NC, not calculated since two NTA and two MAG3 patients received high and low amounts of tracer activity, respectively
Patient 12 withdrew from the study prior to tracer injection
NA, not available
^*Voiding volumes are not comparable since the patient voided prior to the completion of an acquisition