The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

EJNMMI Research

Table 1 Regional estimates of V_T- and BP_ND for test-, and retest scans

Brain region	2TCM			2TCM-c			1TCM			Logan (t* = 60)			2TCM-c
	V_T [mL/cm³]			V_T [mL/cm³]			V_T [mL/cm³]			V_T [mL/cm³]			k₃/k₄ (BP_ND)
	Mean	±	SEM	Mean	±	SEM	Mean	±	SEM	Mean	±	SEM	Mean	±	SEM
Striatum
Test	15.3	±	2.25	15.0	±	1.11	14.2	±	1.29	15.8	±	1.15	1.16	±	0.36
Retest	14.1	±	0.96	15.3	±	0.93	14.8	±	0.61	15.7	±	1.04	1.12	±	0.39
Thalamus
Test	15.6	±	1.98	15.0	±	1.38	13.3	±	1.17	14.9	±	0.99	1.03	±	0.25
Retest	13.0	±	1.08	14.2	±	1.06	13.4	±	0.60	14.3	±	1.11	0.97	±	0.36
Cerebellum
Test	10.6	±	0.08	9.70	±	NA	9.8	±	0.78	11.2	±	0.68	1.24	±	NA
Retest	12.3	±	NA	13.3	±	2.97	10.4	±	0.82	11.1	±	0.75	1.22	±	0.42
White matter
Test	14.0	±	2.37	13.8	±	1.69	12.3	±	1.13	13.9	±	1.00	1.25	±	0.16
Retest	12.6	±	1.08	13.7	±	1.61	12.5	±	0.68	13.6	±	1.23	0.83	±	0.47
Frontal cortex
Test	16.3	±	3.68	14.8	±	2.15	13.8	±	1.64	15.0	±	1.59	1.25	±	0.32
Retest	13.1	±	0.66	14.7	±	1.37	13.8	±	1.15	14.8	±	1.87	1.32	±	0.40
Temporal cortex
Test	13.9	±	1.60	14.8	±	1.30	12.9	±	0.83	14.1	±	0.77	1.00	±	0.24
Retest	14.0	±	0.01	13.1	±	0.76	13.0	±	0.52	13.9	±	0.91	0.97	±	0.54
Parietal cortex
Test	15.5	±	3.24	15.4	±	1.54	14.3	±	1.41	15.4	±	1.35	1.08	±	0.26
Retest	13.6	±	0.36	16.1	±	1.40	14.8	±	0.75	15.7	±	1.43	1.17	±	0.29

V_T was estimated using 2TCM, 2TCM-c, 1TCM and Logan. BP_ND was estimated by k₃/k₄ using a 2TCM-c. Only estimates at < 25%SE were included. NA = undetermined