Fig. 4

Correlation of the significant principal components and age of onset of AD in the temporal lobe. Principal components exhibiting significant correlation with the age of onset of AD \(\left( |r|>0.5; P<0.05/N_{{{\rm ind}}}^r\right)\). A linear regression with 95% confidence bands is shown on the plots for better visualization of the correlations. The features extracted from AD patients in the left lateral part of the anterior temporal lobe (a) and in the left anterior part of the superior temporal gyrus (b) exhibit a significant difference with respect to the background estimated from control subjects, as confirmed also by the Student’s t-test on the distributions of the two patient categories with respect to a threshold age \({\mathcal{A}}\) (c, d)