Table 1 Median and highest Pearson correlation coefficients (provided from correlation coefficients of the 120 brain regions) between PET metabolism and age for each region of intensity normalization in both conventional and digital PET systems
Region for intensity normalization | Conventional PET | Digital PET | ||
|---|---|---|---|---|
Strongest correlation coefficient | Median of correlation coefficients | Strongest correlation coefficient | Median of correlation coefficients | |
Precentral_R | − 0.573688445 | 0.279184148 | − 0.581382052 | 0.293280215 |
Precentral_L | − 0.622302284 | 0.232181965 | − 0.628568612 | 0.266985128 |
Frontal_Sup_R | − 0.600980191 | 0.319870899 | − 0.690629185 | 0.242280289 |
Frontal_Sup_L | − 0.547693637 | 0.405334595 | − 0.599914817 | 0.443110434 |
Frontal_Sup_Orb_R | − 0.629579861 | 0.084998269 | − 0.700581666 | − 0.108439103 |
Frontal_Sup_Orb_L | − 0.547437357 | 0.192820744 | − 0.703649178 | − 0.033764917 |
Frontal_Mid_R | − 0.553053145 | 0.349833531 | − 0.584128133 | 0.463018236 |
Frontal_Mid_L | − 0.551382331 | 0.315606715 | − 0.610512904 | 0.39907714 |
Frontal_Mid_Orb_R | − 0.55913071 | 0.098969813 | − 0.684911592 | − 0.036623595 |
Frontal_Mid_Orb_L | − 0.445475539 | 0.255947537 | − 0.680085738 | 0.1323272 |
Frontal_Inf_Oper_R | − 0.403554772 | 0.451057221 | − 0.584413796 | 0.431311318 |
Frontal_Inf_Oper_L | − 0.346777766 | 0.545425764 | − 0.542003107 | 0.481079751 |
Frontal_Inf_Tri_R | − 0.549174379 | 0.296954014 | − 0.608717652 | 0.267245207 |
Frontal_Inf_Tri_L | − 0.558387379 | 0.286348933 | − 0.653848914 | 0.273189928 |
Frontal_Inf_Orb_R | − 0.52705298 | 0.333803877 | − 0.6524112 | 0.21577136 |
Frontal_Inf_Orb_L | − 0.464517096 | 0.368956454 | − 0.628902165 | 0.32330541 |
Rolandic_Oper_R | − 0.566697841 | 0.243996131 | − 0.678571105 | 0.095847239 |
Rolandic_Oper_L | − 0.618467447 | 0.211708259 | − 0.723144101 | − 0.112062758 |
Supp_Motor_Area_R | − 0.517843026 | 0.180772399 | − 0.460519688 | 0.426544183 |
Supp_Motor_Area_L | − 0.696169862 | − 0.02036436 | − 0.73268581 | 0.039897831 |
Olfactory_R | − 0.388765983 | 0.487926686 | − 0.657210451 | 0.105375048 |
Olfactory_L | − 0.528013879 | 0.384147962 | − 0.721491098 | − 0.122749257 |
Frontal_Sup_Medial_R | − 0.358836732 | 0.524163102 | − 0.488283894 | 0.489288049 |
Frontal_Sup_Medial_L | − 0.573032908 | 0.423672249 | − 0.735839552 | 0.25158455 |
Frontal_Med_Orb_R | − 0.484358087 | 0.39321911 | − 0.615616599 | 0.337668074 |
Frontal_Med_Orb_L | − 0.50075176 | 0.376511335 | − 0.74510263 | 0.041807974 |
Rectus_R | − 0.55071263 | 0.351304466 | − 0.635567564 | 0.035246613 |
Rectus_L | − 0.604668295 | 0.259112277 | − 0.671649932 | − 0.154421386 |
Insula_R | − 0.626506716 | 0.161993577 | − 0.734040284 | − 0.072023968 |
Insula_L | − 0.443959797 | 0.496975678 | − 0.56772327 | 0.513856619 |
Cingulum_Ant_R | − 0.275972126 | 0.634247449 | − 0.400842278 | 0.640119849 |
Cingulum_Ant_L | − 0.692031912 | 0.350939125 | − 0.78453279 | 0.189981663 |
Cingulum_Mid_R | − 0.615009986 | 0.262411063 | − 0.579931165 | 0.467563092 |
Cingulum_Mid_L | − 0.664484269 | 0.167834424 | − 0.730987309 | 0.232708068 |
Cingulum_Post_R | − 0.526277264 | 0.019893397 | − 0.624772162 | 0.120155957 |
Cingulum_Post_L | − 0.555623248 | 0.026567322 | − 0.634707019 | 0.240298045 |
Hippocampus_R | − 0.74488582 | − 0.158224441 | − 0.776691477 | − 0.178442999 |
Hippocampus_L | − 0.792432684 | − 0.401600367 | − 0.794914907 | − 0.355792507 |
ParaHippocampal_R | − 0.547796599 | 0.135694163 | − 0.741894049 | − 0.03170524 |
ParaHippocampal_L | − 0.691581684 | − 0.020746522 | − 0.774862984 | − 0.184001347 |
Amygdala_R | − 0.690685381 | − 0.050409819 | − 0.738301387 | − 0.264093722 |
Amygdala_L | − 0.675326502 | − 0.09187106 | − 0.738046871 | − 0.344906004 |
Calcarine_R | − 0.597218653 | 0.004930533 | − 0.59736577 | 0.209424087 |
Calcarine_L | − 0.641938573 | − 0.076213494 | − 0.693935653 | − 0.086552086 |
Cuneus_R | − 0.726146822 | − 0.154685879 | − 0.621177518 | 0.096712726 |
Cuneus_L | − 0.785087897 | − 0.348003457 | − 0.666285592 | − 0.124622161 |
Lingual_R | − 0.634614302 | − 0.097770865 | − 0.643697071 | − 0.046781064 |
Lingual_L | − 0.685486599 | − 0.166388559 | − 0.670109744 | − 0.04623892 |
Occipital_Sup_R | − 0.701641346 | − 0.194678777 | − 0.646231705 | − 0.064989794 |
Occipital_Sup_L | − 0.741727211 | − 0.306092732 | − 0.597199679 | 0.127544711 |
Occipital_Mid_R | − 0.727813649 | − 0.364255804 | − 0.647178347 | − 0.059276144 |
Occipital_Mid_L | − 0.718730655 | − 0.244437115 | − 0.672193986 | 0.035856165 |
Occipital_Inf_R | − 0.723331225 | − 0.386129463 | − 0.668353467 | − 0.211046407 |
Occipital_Inf_L | − 0.745424761 | − 0.389693675 | − 0.689600876 | − 0.207004321 |
Fusiform_R | − 0.726536142 | − 0.195906801 | − 0.760147469 | − 0.312002428 |
Fusiform_L | − 0.737547599 | − 0.265574857 | − 0.756777592 | − 0.30482379 |
Postcentral_R | − 0.709883189 | 0.024251053 | − 0.626583194 | 0.099793863 |
Postcentral_L | − 0.76459292 | − 0.110140116 | − 0.734129726 | − 0.048775906 |
Parietal_Sup_R | − 0.710966862 | − 0.163768876 | − 0.600734839 | 0.175798905 |
Parietal_Sup_L | − 0.639227666 | − 4.90902E − 05 | − 0.542532856 | 0.337939446 |
Parietal_Inf_R | − 0.620798761 | 0.113031765 | − 0.541267618 | 0.442951513 |
Parietal_Inf_L | − 0.554435839 | 0.25511845 | − 0.519628 | 0.459809369 |
SupraMarginal_R | − 0.642901203 | 0.143077102 | − 0.631066657 | 0.16035289 |
SupraMarginal_L | − 0.67010586 | 0.198101079 | − 0.629274111 | 0.305772909 |
Angular_R | − 0.637290184 | − 0.021187495 | − 0.576971854 | 0.223955824 |
Angular_L | − 0.611346979 | 0.099585441 | − 0.577059191 | 0.293618718 |
Precuneus_R | − 0.745445943 | − 0.14394911 | − 0.687422118 | 0.094901913 |
Precuneus_L | − 0.757202509 | − 0.219708792 | − 0.708572999 | 0.033021343 |
Paracentral_Robule_R | − 0.778348539 | − 0.344721681 | − 0.702759859 | − 0.103953847 |
Paracentral_Robule_L | − 0.784491443 | − 0.417984838 | − 0.794021505 | − 0.424682684 |
Caudate_R | 0.307397852 | 0.497272916 | 0.398152235 | 0.640465612 |
Caudate_L | − 0.524293718 | 0.387711671 | − 0.711582026 | 0.385198422 |
Putamen_R | − 0.602942275 | 0.125257327 | − 0.701652279 | − 0.198897079 |
Putamen_L | − 0.630316648 | − 0.007083048 | − 0.70161431 | − 0.11815898 |
Pallidum_R | − 0.510633293 | 0.20883992 | − 0.770671936 | − 0.407366194 |
Pallidum_L | − 0.448907585 | 0.271878766 | − 0.709597016 | − 0.223370032 |
Thalamus_R | − 0.507908201 | 0.263313022 | − 0.67710738 | 0.302515492 |
Thalamus_L | − 0.654566592 | − 0.060126393 | − 0.74406809 | − 0.109863951 |
Heschl_R | − 0.485771916 | 0.298329103 | − 0.55866801 | 0.43147372 |
Heschl_L | − 0.472564385 | 0.35518222 | − 0.503638686 | 0.575685721 |
Temporal_Sup_R | − 0.625069091 | 0.254407932 | − 0.624234384 | 0.348479101 |
Temporal_Sup_L | − 0.68587206 | 0.168621993 | − 0.652154125 | 0.302844751 |
Temporal_Pole_Sup_R | − 0.331232941 | 0.425860523 | − 0.44600523 | 0.406669675 |
Temporal_Pole_Sup_L | − 0.363542986 | 0.354619085 | − 0.500438422 | 0.380854532 |
Temporal_Mid_R | − 0.690671811 | 0.044779431 | − 0.658061148 | 0.11769236 |
Temporal_Mid_L | − 0.697074384 | 0.064873746 | − 0.638795334 | 0.231016521 |
Temporal_Pole_Mid_R | − 0.451855567 | 0.225791623 | − 0.644696334 | 0.035810993 |
Temporal_Pole_Mid_L | − 0.457567288 | 0.245337503 | − 0.704001434 | 0.029743346 |
Temporal_Inf_R | − 0.68436998 | − 0.104670403 | − 0.696015575 | − 0.063048755 |
Temporal_Inf_L | − 0.669764664 | − 0.031455074 | − 0.689992535 | 0.035977061 |
Cerebelum_Crus1_R | − 0.600476473 | − 0.004144622 | − 0.64067283 | − 0.112577583 |
Cerebelum_Crus1_L | − 0.666707111 | − 0.13413203 | − 0.68045527 | − 0.193184819 |
Cerebelum_Crus2_R | − 0.681004608 | − 0.302210346 | − 0.679835366 | − 0.196911931 |
Cerebelum_Crus2_L | − 0.687555117 | − 0.232091696 | − 0.684717528 | − 0.150689558 |
Cerebelum_3_R | − 0.631993976 | − 0.168105517 | − 0.69448275 | − 0.107741771 |
Cerebelum_3_L | − 0.576269744 | − 0.009951379 | − 0.647040809 | − 0.007816927 |
Cerebelum_4_5_R | − 0.650573984 | − 0.181355372 | − 0.687937783 | − 0.21895484 |
Cerebelum_4_5_L | − 0.663071101 | − 0.077466212 | − 0.730497017 | − 0.123468168 |
Cerebelum_6_R | − 0.677921489 | − 0.155131146 | − 0.710308279 | − 0.303651351 |
Cerebelum_6_L | − 0.735262898 | − 0.279267569 | − 0.716515286 | − 0.28440532 |
Cerebelum_7b_R | − 0.704269564 | − 0.332758809 | − 0.738855392 | − 0.400111216 |
Cerebelum_7b_L | − 0.743454724 | − 0.403805093 | − 0.729542146 | − 0.333328681 |
Cerebelum_8_R | − 0.729481495 | − 0.437717362 | − 0.812531147 | − 0.61846924 |
Cerebelum_8_L | − 0.753248363 | − 0.500101319 | − 0.823696914 | − 0.630973003 |
Cerebelum_9_R | − 0.695106139 | − 0.36420094 | − 0.79927817 | − 0.503436315 |
Cerebelum_9_L | − 0.744673144 | − 0.476228365 | − 0.811756228 | − 0.579151524 |
Cerebelum_10_R | − 0.548985851 | − 0.118360681 | − 0.717244723 | − 0.333550516 |
Cerebelum_10_L | − 0.571047001 | − 0.201373641 | − 0.541209852 | 0.039102255 |
Vermis_1_2 | − 0.644498893 | − 0.180633313 | − 0.732799769 | − 0.208601441 |
Vermis_3 | − 0.584677906 | − 0.134242733 | − 0.671825282 | − 0.096599336 |
Vermis_4_5 | − 0.577923911 | − 0.137586851 | − 0.642737286 | − 0.089295963 |
Vermis_6 | − 0.531525033 | − 0.04047739 | − 0.610495443 | − 0.101942777 |
Vermis_7 | − 0.578924525 | − 0.093968004 | − 0.662218149 | − 0.224039981 |
Vermis_8 | − 0.756376798 | − 0.506853104 | − 0.790218976 | − 0.616443676 |
Vermis_9 | − 0.742895596 | − 0.469781549 | − 0.753866317 | − 0.457157983 |
Vermis_10 | − 0.667363951 | − 0.342948819 | − 0.714105274 | − 0.232058498 |
Midbrain | − 0.71649863 | − 0.13811898 | − 0.748687248 | − 0.13147618 |
Pons | − 0.718410905 | − 0.385970718 | − 0.818592258 | − 0.547892778 |
Medulla | − 0.737949443 | − 0.406080404 | − 0.776357698 | − 0.371013333 |
Whole grey-matter | − 0.738042818 | 0.124152213 | − 0.734258642 | 0.16754782686138 |