Fig. 5

Detail from Fig. 4. Radionuclide distribution was heterogeneous in the viable tumor to the left of region a, and in the small deposit to the right with low uptake in the surrounding liver. There was high uptake in a small, viable deposit to the right of region b but very low uptake in the large, necrotic mass to the left. In region c, there was high uptake in an isolated group of cells (40 × magnification), and its corresponding autoradiograph. Images of the same region of cells (middle row, right and far right, photographed at 100 × and 200 × magnification) demonstrate the ability of ⁶⁴Cu-SARTATE to target small tumor deposits. Region d refers to a tumor deposit that stained strongly for SSTR2 by IHC, then the corresponding autoradiograph showing high uptake in the tumor and low uptake in the surrounding liver. The next image is a × 200 magnification photograph of the same deposit and finally (right) the primary omission control of the same region from a contiguous tissue section confirming specificity of staining