Fig. 2

Small animal positron emission tomography images of a mouse following injection of ⁶⁴Cu-SARTATE. PET/CT Image data were collected at 1, 5, 24 and 48 h post-injection. Mice were anesthetized with isoflurane at 1–4% in a flow of oxygen and data were collected over 30 min using a Bruker Albira PET/SPECT/CT camera. Representative coronal (top and second rows) and transaxial (third and bottom rows) images from one mouse are shown focusing on uptake in ventral intrahepatic metastases. Uptake in the  NB metastases (e.g., tumor indicated by red arrow in 5 h image) was evident throughout the study. The radiolabeled peptide cleared rapidly from most tissues with notable uptake in the kidneys, and liver/tumor. Radioactivity cleared via the bladder (yellow arrow, 1 h image). Clearance via the digestive tract (24 h, white arrow) was also detected. (Scale bars on the top row indicate maximum counts in the images in percentage of injected dose per gram (%IA/g), with no background subtraction.)