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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

Fig. 4

The relationship between ORM-12741 plasma levels and α2C-adrenoceptor occupancy in human a caudate nucleus and b in putamen. The blue line represents binding hyperboles derived from nonlinear regression analysis with a sigmoidal maximum possible effect model. The red lines represent 95% confidence intervals. Concentrations of ORM-12741 in plasma represent mean values of samples collected at the start and end of the PET scan. Each data point represents an individual occupancy value at one time point

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