Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

EJNMMI Research

Table 1 Extraction efficiency of [¹⁸F, ^natGa]rhPSMA-7 from blood, liver, kidney and tumor.

	Tissues	Efficiency [% Extracted radioactivity]
	Tissues	Sample extraction	SPE purification	Overall
Potter–Elvehjem tissue grinder (n = 1)	Kidney	91	66	60
Potter–Elvehjem tissue grinder (n = 1)	Tumor	90	59	53
MM-400 ball mill (n = 3)	Liver	97	89 ± 2	86 ± 2
	Kidney	63 ± 5	68 ± 8	43 ± 8
	Tumor	64 ± 18	65 ± 3	42 ± 14
	Blood (n = 4)	97 ± 2	94 ± 2	90 ± 4

Samples were extracted using either a Potter–Elvehjem tissue grinder (n = 1) or a MM-400 Ball Mill (n = 3). The percentage of activity after sample extraction and after SPE purification was quantified, decay-corrected, and the overall extracted activity was calculated (values are expressed as mean ± SD).