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Table 2 Interobserver agreement

From: RETRACTED ARTICLE: Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer

SPECT

Observer A

Observer B

Observer C

ICC (95% CI)

ICC level of agreement

ROImax (mean ± SD)

ROImax (mean ± SD)

ROImax (mean ± SD)

Malignant lesion(s) ROI

 Primary lung tumour (T)

548 ± 150

560 ± 154

568 ± 157

0.94 (0.90–0.97)

Good to excellent

 Lymph node metastasis (LN)

459 ± 167

461 ± 167

448 ± 163

0.97 (0.95–0.98)

Excellent

Healthy reference tissue

 Blood pool (BP)

260 ± 80

295 ± 80

270 ± 83

0.90 (0.84–0.94)

Good to excellent

 Lung (freehand)

249 ± 146

310 ± 157

251 ± 88

0.84 (0.75–0.90)

Moderate to excellent

 Lung (AA)

279 ± 113

279 ± 108

250 ± 94

0.89 (0.82–0.93)

Good to excellent

 Lung (C)

307 ± 121

286 ± 129

288 ± 128

0.88 (0.81–0.93)

Good to excellent

 Liver (freehand)

1121 ± 274

1262 ± 288

1194 ± 274

0.97 (0.95–0.98)

Excellent

 Liver (GOJ)

1116 ± 264

1185 ± 270

1219 ± 283

0.95 (0.92–0.97)

Excellent

 

ROImax ratio (mean ± SD)

ROImax ratio

ROImax ratio (mean ± SD)

ICC (95% CI)

ICC level of agreement

(mean ± SD)

Ratios

 T:BP

2.29 ± 0.98

1.99 ± 0.67

2.20 ± 0.77

0.83 (0.73–0.90)

Moderate to good

 T:L (freehand)

2.56 ± 1.18

2.01 ± 0.71

2.40 ± 0.86

0.79 (0.68–0.88)

Moderate to good

 T:L (AA)

2.10 ± 0.75

2.17 ± 0.86

2.41 ± 0.90

0.85 (0.77–0.91)

Good to excellent

 T:L (C)

1.92 ± 0.71

2.20 ± 0.92

2.18 ± 0.88

0.80 (0.69–0.88)

Moderate to good

 LN:BP

1.86 ± 0.65

1.65 ± 0.51

1.76 ± 0.66

0.87 (0.81–0.92)

Good to excellent

  1. Malignant lesion and healthy tissue reference measurements (ROImax; mean ± SD) and their ratios of all three observers with intraclass correlation coefficient (ICC), their 95% confidence interval (CI) and descriptive ICC level of agreement
  2. AA aortic arch, BP blood pool, C carina, CI confidence interval, ICC intraclass correlation coefficient, GOJ gastroesophageal junction, L lung, LN lymph node metastasis, ROI region of interest, T primary lung tumour