Table 1 Demographic and clinical characteristics of healthy controls and PD patients
Cohort | Gender (M/F) | Age (years) | Duration of disease (years) | UPDRS | PDRP Z-score | ||||
|---|---|---|---|---|---|---|---|---|---|
Preoperative baseline | Post-operation | Preoperative baseline | Post-operation | ||||||
3 months | 12 months | 3 months | 12 months | ||||||
Cohort I | |||||||||
HC1 | 15/18 | 57.4 ± 10.5 | – | – | – | – | 0 ± 1.0 | – | – |
PD1 | 15/18 | 58.1 ± 10.3 | 4.3 ± 4.1 | 25.2 ± 14.4 | – | – | 2.74 ± 1.18 | – | – |
Cohort II | |||||||||
HC2 | 4/5 | 61.7 ± 7.3 | – | – | – | – | 0 ± 0.52 | – | – |
PD2 (patients underwent DBS) | |||||||||
1 | F | 50 | 8 | 49 | 21 | 60 | 3.01 | 0.11 | 1.83 |
2 | M | 66 | 19 | 62 | 53 | 69 | 1.61 | − 0.18 | 0.17 |
3 | M | 62 | 10 | 51 | 10 | 37 | 2.42 | 1.97 | 2.28 |
4 | F | 72 | 5 | 50 | 12 | 31 | 1.52 | − 0.40 | 0.39 |
5 | M | 53 | 17 | 39 | 30 | – | 4.21 | 2.84 | – |
6 | F | 54 | 13 | 52 | 31 | – | 2.89 | 2.77 | – |
7 | F | 77 | 7 | 51 | 24 | – | 3.71 | 2.53 | – |
8 | F | 69 | 4 | 58 | 56 | – | 2.69 | 2.11 | – |
9 | M | 65 | 6 | 35 | 10 | – | 0.72 | 0.26 | – |
Total | 4/5 | 63.1 ± 9.2 | 9.9 ± 5.3 | 49.7 ± 8.4 | 27.4 ± 17.3 | 49.3 ± 18.2 | 2.53 ± 1.11 | 1.33 ± 1.35 | 1.17 ± 1.04 |