Fig. 3
Patients with metastatic thyroid cancer with greater PSMA uptake than FDG uptake: examples. a, b [68Ga]Ga-PSMA-11 PET MIP (a) and 2-[18F]FDG PET MIP (b) in a patient (Patient 6) with poorly differentiated papillary thyroid carcinoma. Bilateral hilar and mediastinal metastases (circled) are more avid on PSMA (median SUVmax 8.5) than FDG (median SUVmax 4.1). However, a small right middle lobe metastasis seen on FDG (B, small arrow) is not visible on PSMA. C–D: [68Ga]Ga-PSMA-11 PET MIP (c) and 2-[18F]FDG PET MIP (d) in a patient (Patient 5) with follicular thyroid carcinoma. A left 8th costovertebral junction metastasis (large arrows) is more avid on PSMA (SUVmax 15.0) than on FDG (SUVmax 3.5). In addition, a focus of uptake in the lateral right 4th rib (c, small arrow) is only visible on PSMA PET and may represent an additional site of metastatic disease