In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

EJNMMI Research

Table 3 Wilcoxon rank test results for pairwise comparisons in mGluR5 KO and WT mice

Group	Region	SUV_pre Mean ± SD	SUV_post Mean ± SD	W	p value
mGluR5 KO	CTX	2.04 ± 0.33	1.49 ± 0.42	8	0.024*
	HIP	1.90 ± 0.29	1.39 ± 0.40	8	0.024*
	THA	2.20 ± 0.34	1.57 ± 0.43	6	0.014*
	STR	2.10 ± 0.33	1.66 ± 0.47	11	0.054
	CB	2.32 ± 0.39	1.53 ± 0.49	5	0.010**
	WB	2.00 ± 0.31	1.44 ± 0.37	6	0.014*
WT	CTX	2.04 ± 0.68	2.16 ± 0.58	38	0.322
	HIP	1.87 ± 0.63	1.93 ± 0.51	37	0.375
	THA	2.15 ± 0.83	2.15 ± 0.60	30	0.846
	STR	2.11 ± 0.67	2.29 ± 0.61	41	0.193
	CB	2.21 ± 0.79	2.10 ± 0.56	29	0.922
	WB	1.96 ± 0.66	1.99 ± 0.53	34	0.557

KO knockout, WT wild type, SUV standardized uptake value, SD standard deviation, CTX cortex, HIP hippocampus, THA thalamus, STR striatum, CB cerebellum, WB whole brain
^*p < 0.05, **p < 0.01