In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

EJNMMI Research

Table 2 Between-group comparisons of [¹⁸F]FDG PET SUV_pre, SUV_post and ΔSUV with acute MK-801 challenge

Region	Group	SUV_pre Mean ± SD	t	p-value	SUV_post Mean ± SD	t	p-value	ΔSUV (%) Mean ± SD	t	p-value
CTX	mGluR5 KO	2.04 ± 0.33	0.00	0.998	1.49 ± 0.42	− 3.00	0.007**	− 24.0 ± 29.5	− 2.64	0.016*
CTX	WT	2.04 ± 0.68	0.00	0.998	2.16 ± 0.58	− 3.00	0.007**	12.8 ± 31.8	− 2.64	0.016*
HIP	mGluR5 KO	1.90 ± 0.29	0.11	0.912	1.39 ± 0.40	− 2.40	0.027*	− 23.6 ± 29.4	− 2.49	0.022*
HIP	WT	1.87 ± 0.63	0.11	0.912	1.93 ± 0.51	− 2.40	0.027*	11.1 ± 34.2	− 2.49	0.022*
THA	mGluR5 KO	2.20 ± 0.34	0.22	0.825	1.57 ± 0.43	− 2.60	0.018*	− 25.9 ± 28.1	− 2.64	0.016*
THA	WT	2.15 ± 0.83	0.22	0.825	2.15 ± 0.60	− 2.60	0.018*	11.0 ± 39.4	− 2.64	0.016*
STR	mGluR5 KO	2.10 ± 0.33	− 0.05	0.961	1.66 ± 0.47	− 2.81	0.011*	− 17.5 ± 32.4	− 2.30	0.033*
STR	WT	2.11 ± 0.67	− 0.05	0.961	2.29 ± 0.61	− 2.81	0.011*	14.7 ± 30.4	− 2.30	0.033*
CB	mGluR5 KO	2.32 ± 0.39	0.47	0.643	1.53 ± 0.49	− 2.54	0.020*	− 30.1 ± 33.0	− 2.37	0.028*
CB	WT	2.21 ± 0.79	0.47	0.643	2.10 ± 0.56	− 2.54	0.020*	3.0 ± 30.9	− 2.37	0.028*
WB	mGluR5 KO	2.00 ± 0.31	0.20	0.845	1.44 ± 0.37	− 2.79	0.011*	− 25.4 ± 27.6	− 2.65	0.016*
WB	WT	1.96 ± 0.66	0.20	0.845	1.99 ± 0.53	− 2.79	0.011*	9.3 ± 32.4	− 2.65	0.016*

SUV standardized brain uptake value for [¹⁸F]FDG, ΔSUV the percent change of SUV, SD standard deviation, KO knockout, WT wild type, CTX cortex, HIP hippocampus, THA thalamus, STR striatum, CB cerebellum, WB whole brain
^*p < 0.05, **p < 0.01