Skip to main content

Table 2 Between-group comparisons of [18F]FDG PET SUVpre, SUVpost and ΔSUV with acute MK-801 challenge

From: In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

Region Group SUVpre
Mean ± SD
t p-value SUVpost
Mean ± SD
t p-value ΔSUV (%) Mean ± SD t p-value
CTX mGluR5 KO 2.04 ± 0.33 0.00 0.998 1.49 ± 0.42 − 3.00 0.007** − 24.0 ± 29.5 − 2.64 0.016*
WT 2.04 ± 0.68 2.16 ± 0.58 12.8 ± 31.8
HIP mGluR5 KO 1.90 ± 0.29 0.11 0.912 1.39 ± 0.40 − 2.40 0.027* − 23.6 ± 29.4 − 2.49 0.022*
WT 1.87 ± 0.63 1.93 ± 0.51 11.1 ± 34.2
THA mGluR5 KO 2.20 ± 0.34 0.22 0.825 1.57 ± 0.43 − 2.60 0.018* − 25.9 ± 28.1 − 2.64 0.016*
WT 2.15 ± 0.83 2.15 ± 0.60 11.0 ± 39.4
STR mGluR5 KO 2.10 ± 0.33 − 0.05 0.961 1.66 ± 0.47 − 2.81 0.011* − 17.5 ± 32.4 − 2.30 0.033*
WT 2.11 ± 0.67 2.29 ± 0.61 14.7 ± 30.4
CB mGluR5 KO 2.32 ± 0.39 0.47 0.643 1.53 ± 0.49 − 2.54 0.020* − 30.1 ± 33.0 − 2.37 0.028*
WT 2.21 ± 0.79 2.10 ± 0.56 3.0 ± 30.9
WB mGluR5 KO 2.00 ± 0.31 0.20 0.845 1.44 ± 0.37 − 2.79 0.011* − 25.4 ± 27.6 − 2.65 0.016*
WT 1.96 ± 0.66 1.99 ± 0.53 9.3 ± 32.4
  1. SUV standardized brain uptake value for [18F]FDG, ΔSUV the percent change of SUV, SD standard deviation, KO knockout, WT wild type, CTX cortex, HIP hippocampus, THA thalamus, STR striatum, CB cerebellum, WB whole brain
  2. *p < 0.05, **p < 0.01