[11C]PIB amyloid quantification: effect of reference region selection

EJNMMI Research

Table 3 Test–retest cohort: correlations between reference tissue methods with varying RRs and the gold standard: DVR_{PI_GMCB}

Reference region	DVR_RLOGAN	DVR_SRTM	SUVr₄₀₋₆₀	SUVr₆₀₋₉₀
GM Cerebellum
r	0.88	0.85	0.81	0.89
Slope	0.85	0.85	1.04	1.12
Intercept	0.14	0.18	− 0.03	− 0.10
Whole Cerebellum
r	0.85	0.81	0.77	0.84
Slope	0.81	0.84	1.00	1.05
Intercept	0.09	0.03	− 0.11	− 0.15
WM Brainstem /Pons
r	0.81	0.84	0.78	0.80
Slope	0.73	0.62	0.81	0.91
Intercept	− 0.07	0.04	− 0.24	− 0.30
Whole Brainstem Subcortical
r	0.81	0.83	0.79	0.80
Slope	0.74	0.58	0.83	0.92
Intercept	− 0.06	0.11	− 0.24	− 0.29
Eroded WM
r	0.83	0.86	0.82	0.86
Slope	0.57	0.52	0.67	0.63
Intercept	0.07	0.13	− 0.10	− 0.08

Values are shown for each of the methods and correspond to the linear regression analysis