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Table 3 Metabolite analysis of [11C]4 in male ddY mice

From: Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography

Components Rf value Plasma metabolites (%) Brain metabolites (%)
5 min 15 min 5 min 15 min
HM1 0.09 7.87 ± 2.17 26.65 ± 3.40 0.03 ± 0.02 0.03 ± 0.02
HM2 0.25 53.25 ± 6.59 59.06 ± 6.13 0.01a 0.13 ± 0.02
HM3 0.36 0.54 ± 0.26 0.04a 0.09a 0.02a
Unchanged 0.44 38.29 ± 6.52 14.76 ± 2.23 99.87 ± 0.03 99.84 ± 0.04
LM 0.63 0.05 ± 0.03 0.01 ± 0.01 N.D. N.D.
  1. Data represent the mean ± SD (n = 3)
  2. N.D. not detected, HM hydrophilic metabolite, LM lipophilic metabolite
  3. aDetected in two samples