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EJNMMI Research

Table 2 Effect of acetazolamide on the distribution of [11C]4 in male ddY mice 2 min after injection

From: Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography

Tissue

Vehicle

Acetazolamide

Increase (%)

P

Blood

0.35 ± 0.06

0.33 ± 0.03

94.3

N.S.

Heart

1.62 ± 0.37

1.51 ± 0.20

93.2

N.S.

Lung

8.99 ± 1.96

4.58 ± 1.44

51.0

< 0.05

Liver

0.78 ± 0.10

1.05 ± 0.16

134.6

N.S.

Kidney

6.46 ± 0.99

5.85 ± 1.21

90.6

N.S.

Brain

1.90 ± 0.36

2.60 ± 0.13

136.8

< 0.05

Brain/blood

5.53 ± 1.12

8.01 ± 0.79

144.9

< 0.05

  1. The radioactivity levels are expressed as SUVs
  2. Data represent the mean ± SD (n = 5)
  3. Unpaired t test corrected for multiple comparison using the Holm–Sidak method
  4. N.S. not significant
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