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Table 2 Effect of acetazolamide on the distribution of [11C]4 in male ddY mice 2 min after injection

From: Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography

Tissue Vehicle Acetazolamide Increase (%) P
Blood 0.35 ± 0.06 0.33 ± 0.03 94.3 N.S.
Heart 1.62 ± 0.37 1.51 ± 0.20 93.2 N.S.
Lung 8.99 ± 1.96 4.58 ± 1.44 51.0 < 0.05
Liver 0.78 ± 0.10 1.05 ± 0.16 134.6 N.S.
Kidney 6.46 ± 0.99 5.85 ± 1.21 90.6 N.S.
Brain 1.90 ± 0.36 2.60 ± 0.13 136.8 < 0.05
Brain/blood 5.53 ± 1.12 8.01 ± 0.79 144.9 < 0.05
  1. The radioactivity levels are expressed as SUVs
  2. Data represent the mean ± SD (n = 5)
  3. Unpaired t test corrected for multiple comparison using the Holm–Sidak method
  4. N.S. not significant