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EJNMMI Research
Fig. 3 | EJNMMI Research

Fig. 3

From: [11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

Fig. 3

Standard PET images of myocardium after i.v. injection of [11C]mHED or [18F]LMI1195 in FVB/N mice. a Representative short-axis (left column), horizontal long-axis (middle column), and vertical long-axis (right column) PET images at various extents of NET saturation with metaraminol (mHED with indication of total mass of [11C]mHED and metaraminol) or desipramine (20 mg/kg desipramine HCl as indicated) and [18F]LMI1195 under baseline conditions or with desipramine. SUV was averaged from 1 to 31 min p.i. b TACs after injection of [11C]mHED alone (9.2–16.6 nmol/kg, including metaraminol mass; n = 3) and [11C]mHED (9.6–10.5 nmol/kg) + 20 mg/kg desipramine HCl (n = 3). c TACs after injection of [18F]LMI1195 alone (mass range, see Table 1; n = 6) and [18F]LMI1195 (mass range, see Table 1) + 20 mg/kg desipramine HCl (n = 6). Mean values with SD

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