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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: [11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

Fig. 2

Compartment models evaluated in this study. a One-tissue compartment model (TCM1). b Model with two parallel tissue compartments (TCM2p) both directly accessible from the input compartment. c Two-tissue compartment model with the two-tissue compartments in series (TCM2s), as applied for neuroreceptor PET. K1 or k3 would represent NET uptake. In the first case, k3 would represent uptake into storage vesicles by vMAT2. In the latter case, K1 would represent extravasation into interstitium. d Similar as c but with the second-tissue compartment releasing to the input compartment (k4) rather than to the first tissue compartment. In this model, K1 would represent NET uptake, k3 uptake into storage vesicles by vMAT2, and k4 release from storage vesicles into interstitial space (TCM2v, v for release from vesicles). Ca, [11C]mHED activity concentration in arterial plasma (input function)

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