Fig. 9

Comparison of metabolic profiles of (+)-[¹⁸F]1 (in vivo vs. in vitro) and identification of radiometabolites. Representative radio-HPLC chromatograms of samples obtained from human subjects: (a) plasma, 15 min; (b) plasma, 30 min; (c) urine, 95 min after injection; and (d) after HLM incubation (NADPH, UDPGA, TRIS, pH 8.4, 37 C, 120 min). Scaling was adjusted for each chromatogram. Adapted with permission from Ref. [71]