Comparison of metabolic profiles of
(+)-[18F]1 (in vivo vs. in vitro)
and identification of radiometabolites. Representative
radio-HPLC chromatograms of samples obtained from human
subjects: (a) plasma, 15 min; (b) plasma, 30 min; (c) urine,
95 min after injection; and (d) after HLM incubation (NADPH,
UDPGA, TRIS, pH 8.4, 37 C, 120 min). Scaling was adjusted for
each chromatogram. Adapted with permission from Ref.