Fig. 7
Gross pathology and microdosimetry for P5. a Pre-treatment T2 FLAIR 1 month prior to therapy. b Formalin-fixed gross pathologic example of involved hemisphere with significant central tumor necrosis. c Microdosimetry showing the absorbed-dose distribution in dog P5 if the dog had survived. At the time of death, only 15% of the absorbed-doses shown had been delivered based on the half-life of 90Y. d Post-explant microCT showing gross distribution of glass microspheres. Image is a maximum intensity projection of 100 microCT slices with a combined thickness of 900 um. A preference for deposition in the peri-necrotic region of tumor can be seen (white arrows). Occasional filling of end-arterioles/capillaries with microspheres can be visualized (red arrow)