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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

Fig. 2

In vivo and ex vivo tumor fluorescent signal increases over time after 20 nmol VGT-309 injection. a Representative fluorescent images from the IVIS spectrum of tumor-bearing mice at different time points post intravenous injection VGT-309 and the control mouse without tumor inoculation. Six mice were evaluated per group. The upper panels demonstrate fluorescent images with the same scale. The lower panels show the optimal fluorescence contrast at each time point. b Quantitative fluorescent signal from the Pearl imager shows changes in fluorescent signal of tumor and background muscle tissue and tumor-to-background ratio (TBR) at different time point after intravenous injection of VGT-309. n = 6 for each time point. All data are presented as mean ± standard error

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