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Fig. 6 | EJNMMI Research

Fig. 6

From: 177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma

Fig. 6

Biodistribution of [177Lu]Lu-1C1m-Fc in Balb/c nu mice. a TEM-1 negative tumor (HT-1080)-bearing mice with Kiovig™ preinjection, group 1. b TEM-1 positive tumor (SK-N-AS)-bearing mice with Kiovig™ preinjection, group1. c TEM-1 positive tumor (SK-N-AS)-bearing mice without Kiovig™ preinjection, group 2. Data are shown as mean ± SD. There were significant differences between uptake in TEM-1 positive tumors compared with TEM-1 negative tumors (p = 0.0006 at 24 h). There was no difference on the biodistribution with or without Kiovig™ preinjection (all p > 0.059)

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